Nanoparticle toxicology

W Yang, L Wang, EM Mettenbrink… - Annual Review of …, 2021 - annualreviews.org
Nanoparticles from natural and anthropogenic sources are abundant in the environment,
thus human exposure to nanoparticles is inevitable. Due to this constant exposure, it is …

Cytotoxicity and genotoxicity evaluation of chemically synthesized and functionalized upconversion nanoparticles

AA Ansari, AK Parchur, Y Li, T Jia, R Lv, Y Wang… - Coordination Chemistry …, 2024 - Elsevier
Upconversion nanoparticles (UCNPs) show attractive anti-Stokes characteristics converting
lower-energy photons into higher-energy emissions. The excellent biocompatibility and …

Strategies for delivering nanoparticles across tumor blood vessels

V Sheth, L Wang, R Bhattacharya… - Advanced functional …, 2021 - Wiley Online Library
Nanoparticle transport across tumor blood vessels is a key step in nanoparticle delivery to
solid tumors. However, the specific pathways and mechanisms of this nanoparticle delivery …

Nanoparticle surface engineering with heparosan polysaccharide reduces serum protein adsorption and enhances cellular uptake

W Yang, L Wang, M Fang, V Sheth, Y Zhang… - Nano …, 2022 - ACS Publications
Nanoparticle modification with poly (ethylene glycol)(PEG) is a widely used surface
engineering strategy in nanomedicine. However, since the artificial PEG polymer may …

Engineering at the nano-bio interface: harnessing the protein corona towards nanoparticle design and function

RL Pinals, L Chio, F Ledesma, MP Landry - Analyst, 2020 - pubs.rsc.org
Unpredictable and uncontrollable protein adsorption on nanoparticles remains a
considerable challenge to achieving effective application of nanotechnologies within …

Exploring and analyzing the systemic delivery barriers for nanoparticles

L Wang, S Quine, AN Frickenstein… - Advanced Functional …, 2024 - Wiley Online Library
Most nanomedicines require efficient in vivo delivery to elicit meaningful diagnostic and
therapeutic effects. However, en route to their intended tissues, systemically administered …

Quantifying intracellular nanoparticle distributions with three-dimensional super-resolution microscopy

V Sheth, X Chen, EM Mettenbrink, W Yang, MA Jones… - ACS …, 2023 - ACS Publications
Super-resolution microscopy can transform our understanding of nanoparticle–cell
interactions. Here, we established a super-resolution imaging technology to visualize …

Controlling nanoparticle uptake in innate immune cells with heparosan polysaccharides

W Yang, AN Frickenstein, V Sheth, A Holden… - Nano …, 2022 - ACS Publications
We used heparosan (HEP) polysaccharides for controlling nanoparticle delivery to innate
immune cells. Our results show that HEP-coated nanoparticles were endocytosed in a time …

Quantification of monodisperse and biocompatible gold nanoparticles by single-particle ICP-MS

AN Frickenstein, S Mukherjee, T Harcourt, Y He… - Analytical and …, 2023 - Springer
Bioanalytical and biomedical applications often require nanoparticles that exhibit narrow
size distributions and biocompatibility. Here, we demonstrate how different synthesis …

Lipid-mediated ex vivo cell surface engineering for augmented cellular functionalities

S Kim, K Kim - Biomaterials Advances, 2022 - Elsevier
Once administrated, intercellular adhesion to recognize and/or arrest target cells is essential
for specific treatments, especially for cancer or tumor. However, immune cells administrated …