Germinal center (GC) B cells are the source of the high-affinity, class-switched antibodies
required for protective immunity. The unique biology of GC B cells involves iterative rounds …

The term ferroptosis was put forward in 2012 and has been researched exponentially over
the past few years. Ferroptosis is an unconventional pattern of iron-dependent programmed …

Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …

Enzymes of the TET family are methylcytosine dioxygenases that undergo frequent
mutational or functional inactivation in human cancers. Recurrent loss-of-function mutations …

Effective vaccines are vital to fight against the COVID-19 global pandemic. As a critical
component of a subunit vaccine, the adjuvant is responsible for strengthening the antigen …

Ten-eleven translocation (TET) proteins are iron-dependent and α-ketoglutarate-dependent
dioxygenases that sequentially oxidize the methyl group of 5-methylcytosine (5mC) to 5 …

Amino acid metabolism plays a pivotal role in tumor microenvironment, influencing various
aspects of cancer progression. The metabolic reprogramming of amino acids in tumor cells …

Hematopoiesis is a dynamic process in which stem and progenitor cells give rise to the~ 10
13 blood and immune cells distributed throughout the human body. We argue that a …

TET2, a member of ten-eleven translocation (TET) family as α-ketoglutarate-and Fe2+-
dependent dioxygenase catalyzing the iterative oxidation of 5-methylcytosine (5mC), has …

Appropriate regulation of B cell differentiation into plasma cells is essential for humoral
immunity while preventing antibody-mediated autoimmunity; however, the underlying …