Phytochemical, ethanomedicinal and pharmacological applications of escin from Aesculus hippocastanum L. towards future medicine

S Idris, A Mishra, M Khushtar - … of Basic and Clinical Physiology and …, 2020 - degruyter.com
Medicinal plants are used from ancient times for treatment of various ailments. Aesculus
hippocastanum (Horse chestnut), is the popular and most valuable tree native to the South …

Neuroinflammation in Parkinson's disease animal models: a cell stress response or a step in neurodegeneration?

C Cebrián, JD Loike, D Sulzer - Behavioral Neurobiology of Huntington's …, 2015 - Springer
The motor symptoms of Parkinson's disease are due to the progressive degeneration of
dopaminergic neurons in the substantia nigra. Multiple neuroinflammatory processes are …

Reassessment of subacute MPTP-treated mice as animal model of Parkinson's disease

Q Zhang, Y Heng, Z Mou, J Huang, Y Yuan… - Acta pharmacologica …, 2017 - nature.com
Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) mouse model remains the most
commonly used animal model of Parkinson's disease (PD). There are three MPTP-treatment …

Neuroprotective effect of lycopene against MPTP induced experimental Parkinson's disease in mice

A Prema, U Janakiraman, T Manivasagam… - Neuroscience …, 2015 - Elsevier
Parkinson's disease (PD) is the second most common neurodegenerative disorder that
mainly affects the movement of the aged populations. Lycopene is a carotenoid with unique …

Lutein protects dopaminergic neurons against MPTP-induced apoptotic death and motor dysfunction by ameliorating mitochondrial disruption and oxidative stress

J Nataraj, T Manivasagam, AJ Thenmozhi… - Nutritional …, 2016 - Taylor & Francis
Objective: Mitochondrial dysfunction and oxidative stress-mediated apoptosis plays an
important role in various neurodegenerative diseases including Huntington's disease …

Ginkgo biloba protects striatal neurodegeneration and gut phagoinflammatory damage in rotenone‐induced mice model of Parkinson's disease: Role of executioner …

OG Adebayo, JN Asiwe, B Ben‐Azu… - Journal of Food …, 2022 - Wiley Online Library
Asymptomatic and early clinical stages of Parkinson's disease (PD) have been linked with
comorbid non‐motor symptoms including dysfunction of the gastrointestinal (GI) tract …

Protective effect of curcumin against oxidative stress-induced injury in rats with Parkinson's disease through the Wnt/β-catenin signaling pathway

YL Wang, B Ju, YZ Zhang, HL Yin, YJ Liu… - Cellular Physiology and …, 2017 - karger.com
Background/Aims: The study aimed to investigate the protective effect of curcumin against
oxidative stress-induced injury of Parkinson's disease (PD) through the Wnt/β-catenin …

Ginsenoside Rg1 attenuates motor impairment and neuroinflammation in the MPTP-probenecid-induced parkinsonism mouse model by targeting α-synuclein …

Y Heng, QS Zhang, Z Mu, JF Hu, YH Yuan, NH Chen - Toxicology Letters, 2016 - Elsevier
Parkinson's disease (PD) is pathologically characterized by the progressive loss of
dopaminergic neurons in the substantia nigra pars compacta (SNpc) and the accumulation …

Catalpol exerts a neuroprotective effect in the MPTP mouse model of Parkinson's disease

LY Wang, X Yu, XX Li, YN Zhao, CY Wang… - Frontiers in Aging …, 2019 - frontiersin.org
The degeneration of dopaminergic (DA) neurons in Parkinson's disease (PD) is related to
inflammation and oxidative stress. Anti-inflammatory agents could reduce the risk or slow the …

Neurotrophic Effect of Asiatic acid, a Triterpene of Centella asiatica Against Chronic 1-Methyl 4-Phenyl 1, 2, 3, 6-Tetrahydropyridine Hydrochloride/Probenecid Mouse …

J Nataraj, T Manivasagam, A Justin Thenmozhi… - Neurochemical …, 2017 - Springer
Regulation of various signalling (Ras-MAPK, PI3K and AKT) pathways by augmented
activity of neurotrophic factors (NTFs) could prevent or halt the progress of dopaminergic …