The mammalian intestine is an organ that can be spatially defined by two axes: longitudinal
and vertical. Such anatomical structure ensures the maintenance of a relatively immuno …

Human limbs emerge during the fourth post-conception week as mesenchymal buds, which
develop into fully formed limbs over the subsequent months. This process is orchestrated by …

The largest mammalian organ, skin, consisting of a dermal connective tissue layer that
underlies and supports the epidermis, acts as a protective barrier that excludes external …

Objectives Systemic sclerosis (SSc) is characterised by extensive tissue fibrosis maintained
by mechanotranductive/proadhesive signalling. Drugs targeting this pathway are therefore …

Stem cell-based therapy has drawn attention as an alternative option for promoting
prosthetic osteointegration in osteoporosis by virtue of its unique characteristics. However …

The myotendinous junction (MTJ) contributes to the generation of motion by connecting
muscle to tendon. At the adult MTJ, a specialized extracellular matrix (ECM) is thought to …

Purpose Pterygium is a vision-threatening conjunctival fibrovascular degenerated disease
with a high global prevalence up to 12%, while no absolute pharmacotherapy has been …

The musculoskeletal system relies on the integration of multiple components with diverse
physical properties, such as striated muscle, tendon, and bone, that enable locomotion and …

Synovial sarcoma is an aggressive soft-tissue malignancy that is characterized by a
pathognomonic t (X; 18)(p11. 2; q11. 2) translocation, which produces the fusion oncogene …

Tissue-resident stem cells are essential for development and repair, and in the skeleton this
function is fulfilled by recently identified skeletal stem cells (SSCs). However, recent work …