Sex steroid hormones are involved in the metabolism, accumulation and distribution of
adipose tissues. It is now known that oestrogen receptor, progesterone receptor and …

The amino acid sequence of caveolin-1 predicts that it is an integral membrane protein, and
there is strong experimental evidence that it has this property. For example, caveolin-1 is …

Estrogen receptor (ER) α variants have been identified in an array of nonendothelial cells.
We previously demonstrated that estrogen rapidly induces nitric oxide release via a …

The development of acquired resistance to ErbB2 tyrosine kinase inhibitors limits the clinical
efficacy of this class of cancer therapeutics. Little is known about the mechanism (s) of …

Recently, it was shown that caveolin-1 can be redirected from the cell surface to intracellular
lipid droplets in a variety of cell types. Here, we directly address the role of caveolin-1 in lipid …

Based on the observation that the Na+/K+-ATPase α subunit contains two conserved
caveolin-binding motifs, we hypothesized that clustering of the Na+/K+-ATPase and its …

It is estimated that in 2017 there were 451 million people with diabetes worldwide. These
figures are expected to increase to 693 million by 2045; thus, innovative preventative …

Estrogen receptors (ER) have been localized to the cell plasma membrane (PM), where
signal transduction mediates some estradiol (E2) actions. However, the precise structural …

Caveolins (Cavs) are integrated plasma membrane proteins that are complex signaling
regulators with numerous partners and whose activity is highly dependent on cellular …

In addition to nuclear-initiated (genomic) responses, estrogen receptors (ERs) have the
ability to facilitate rapid, membrane-initiated, estrogen-triggered signaling cascades via a …