Obesity is associated with chronic inflammation, which contributes to insulin resistance and
type 2 diabetes mellitus. Under normal conditions, skeletal muscle is responsible for the …

Cancers | Free Full-Text | Obesity-Induced TNFα and IL-6 Signaling: The Missing Link between
Obesity and Inflammation—Driven Liver and Colorectal Cancers Next Article in Journal Effects …

Nonalcoholic fatty liver disease (NAFLD) is a growing worldwide epidemic and an important
risk factor for the development of insulin resistance, type 2 diabetes, nonalcoholic …

In the wake of the worldwide increase in type-2 diabetes, a major focus of research is
understanding the signaling pathways impacting this disease. Insulin signaling regulates …

We investigated the relationship between gut health, visceral fat dysfunction and metabolic
disorders in diet-induced obesity. C57BL/6J mice were fed control or high saturated fat diet …

Diabetes mellitus are complex, multi‐organ metabolic pathologies characterized by
hyperglycemia. Emerging evidence shows that the highly conserved and potent JAK/STAT …

Interleukin (IL)-6-type cytokines are critically involved in health and disease. The duration
and strength of IL-6-type cytokine-mediated signaling is tightly regulated to avoid …

The circadian clock controls metabolic and physiological processes through finely tuned
molecular mechanisms. The clock is remarkably plastic and adapts to exogenous" …

Individuals who are obese are frequently insulin resistant, putting them at increased risk of
developing type 2 diabetes and its associated adverse health conditions. The accumulation …

Adipose tissue secretes adipokines that mediate insulin resistance, a characteristic feature
of obesity and type 2 diabetes. By differential proteome analysis of cellular models of insulin …