A comprehensive review of furan in foods: From dietary exposures and in vivo metabolism to mitigation measures

Y Zhang, Y Zhang - … Reviews in Food Science and Food Safety, 2023 - Wiley Online Library
Furan is a thermal food processing contaminant that is ubiquitous in various food products
such as coffee, canned and jarred foods, and cereals. A comprehensive summary of …

Risks for public health related to the presence of furan and methylfurans in food

EFSA Panel on Contaminants in the Food Chain … - EFSA …, 2017 - Wiley Online Library
Abstract The European Commission asked EFSA for a scientific evaluation on the risk to
human health of the presence of furan and methylfurans (2‐methylfuran, 3‐methylfuran and …

Spirulina platensis attenuates furan reprotoxicity by regulating oxidative stress, inflammation, and apoptosis in testis of rats

YM Abd El-Hakim, WA Mohamed… - … and environmental safety, 2018 - Elsevier
Furan is a common food contaminant and environmental pollutant. Spirulina platensis (SP)
is a blue–green algae extensively used as therapeutic and health supplements. This study …

Industrial furan and its biological effects on the body systems

M Alizadeh, M Barati, S Saleh‐Ghadimi… - Journal of Food …, 2018 - Wiley Online Library
Furan as a product of thermal processing is found in many foods and beverages. In vitro and
in vivo genotoxicity was positive for furan, also when metabolic preconditions for the …

Lead-mediated inhibition of lysine acetylation and succinylation causes reproductive injury of the mouse testis during development

Q Yang, X Liu, J Chen, Y Wen, H Liu, Z Peng… - Toxicology Letters, 2020 - Elsevier
Lead (Pb), a widespread heavy metal, may induce serious diseases, particularly male
reproductive injury. However, the mechanisms by which Pb induces testicular injury remain …

Integrated proteomics, biological functional assessments, and metabolomics reveal toosendanin-induced hepatic energy metabolic disorders

X Yan, Y Zhuo, X Bian, J Li, Y Zhang, L Ma… - Chemical Research …, 2019 - ACS Publications
Toosendanin (TSN), a compound from Melia toosendan, exhibits severe hepatotoxicity,
which restricts its clinical application. However, the mechanism is not clear. Our previous …

Assessment of the oxidative damage and apoptotic pathway related to furan cytotoxicity in cultured mouse Leydig cells

Y Aydin, B Yilmaz, YU Dikbasan… - Toxicology …, 2023 - academic.oup.com
Research on heat-induced food contamination is being given more attention as a result of
the health risks that have been publicly revealed in recent years. Furan is known as a …

Proteomic Analysis of Subchronic Furan Exposure in the Liver of Male Fischer F344 Rats

S Gill, M Kavanagh, C Poirier, R Xie… - Toxicologic …, 2022 - journals.sagepub.com
Furan is a volatile compound formed during the thermal processing of foods. Chronic
exposure has been shown to cause cholangiocarcinoma and hepatocellular tumors in …

Impact of PCBs, furan and dioxin on hepatocarcinogenesis

M Helal, S Ghanem, A El-Sikaily - Persistent Organic Pollutants …, 2022 - books.google.com
Stockholm Convention defined polychlorinated biphenyls (PCBs) as a group of persistent
organic pollutants (POPs) such as dioxin/furan, dichlorodiphenyltrichloroethane …

Bioactivation of diclofenac in human hepatocytes and the proposed human hepatic proteins modified by reactive metabolites

K Inoue, H Mizuo, T Ishida, T Komori, K Kusano - Xenobiotica, 2020 - Taylor & Francis
To reveal putative bioactivation pathways of diclofenac, in vitro human liver materials such
as microsomal fractions and hepatocytes were used to confirm metabolic activation of …