Neutrophils represent the first line of cellular defense against invading microorganism by
rapidly moving across the blood–endothelial cell (EC) barrier and exerting effector cell …

The endothelium functions as a semipermeable barrier regulating tissue fluid homeostasis
and transmigration of leukocytes and providing essential nutrients across the vessel wall …

The migration of neutrophils into inflamed tissues is a fundamental component of innate
immunity. A decisive step in this process is the polarized migration of blood neutrophils …

Mechanical stress from blood flow has a significant effect on endothelial physiology, with a
key role in initiating vasoregulatory signals. Disturbances in blood flow, such as in regions of …

Cancer cells can move through tissues in a variety of different ways. In some cases, an
epithelial-to-mesenchymal transition enables cancer cells to acquire fibroblast-like migratory …

Diabetic retinopathy is associated with ocular inflammation, leading to retinal barrier
breakdown, macular edema, and visual cell loss. We investigated the molecular …

Vascular permeability is a highly coordinated process that integrates vesicular trafficking,
complex junctional rearrangements, and refined cytoskeletal dynamics. In response to the …

The unquestionable role of neutrophils in the development and progression of inflammatory
conditions suggests that a better understanding of the tissue-specific and stimulus-specific …

Recruitment of neutrophils from the blood circulation to sites of infection or injury is a key
innate immune response against invading pathogens and tissue injury. However, if …

The neutrophil transmigration across the blood endothelial cell barrier represents the
prerequisite step of innate inflammation. Neutrophil recruitment to inflamed tissues occurs in …