In vivo brain GSH: MRS methods and clinical applications

F Bottino, M Lucignani, A Napolitano, F Dellepiane… - Antioxidants, 2021 - mdpi.com
Glutathione (GSH) is an important antioxidant implicated in several physiological functions,
including the oxidation− reduction reaction balance and brain antioxidant defense against …

Preprocessing, analysis and quantification in single‐voxel magnetic resonance spectroscopy: experts' consensus recommendations

J Near, AD Harris, C Juchem, R Kreis… - NMR in …, 2021 - Wiley Online Library
Once an MRS dataset has been acquired, several important steps must be taken to obtain
the desired metabolite concentration measures. First, the data must be preprocessed to …

The trajectory of cortical GABA across the lifespan, an individual participant data meta-analysis of edited MRS studies

EC Porges, G Jensen, B Foster, RAE Edden, NAJ Puts - Elife, 2021 - elifesciences.org
γ-Aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the human brain
and can be measured with magnetic resonance spectroscopy (MRS). Conflicting accounts …

Spectral editing in 1H magnetic resonance spectroscopy: Experts' consensus recommendations

IY Choi, OC Andronesi, P Barker, W Bogner… - NMR in …, 2021 - Wiley Online Library
Spectral editing in in vivo 1H‐MRS provides an effective means to measure low‐
concentration metabolite signals that cannot be reliably measured by conventional MRS …

Prediction learning in adults with autism and its molecular correlates

LA Sapey-Triomphe, J Temmerman, NAJ Puts… - Molecular autism, 2021 - Springer
Abstract Background According to Bayesian hypotheses, individuals with Autism Spectrum
Disorder (ASD) have difficulties making accurate predictions about their environment. In …

Motion correction in magnetic resonance spectroscopy

MG Saleh, RAE Edden, L Chang… - Magnetic resonance in …, 2020 - Wiley Online Library
In vivo proton magnetic resonance spectroscopy and spectroscopic imaging (MRS/MRSI)
are valuable tools to study normal and abnormal human brain physiology. However, they …

Correcting frequency and phase offsets in MRS data using robust spectral registration

M Mikkelsen, S Tapper, J Near… - NMR in …, 2020 - Wiley Online Library
An algorithm for retrospective correction of frequency and phase offsets in MRS data is
presented. The algorithm, termed robust spectral registration (rSR), contains a set of …

Multi-vendor standardized sequence for edited magnetic resonance spectroscopy

MG Saleh, D Rimbault, M Mikkelsen, G Oeltzschner… - Neuroimage, 2019 - Elsevier
Spectral editing allows direct measurement of low-concentration metabolites, such as GABA,
glutathione (GSH) and lactate (Lac), relevant for understanding brain (patho) physiology …

Advanced Hadamard-encoded editing of seven low-concentration brain metabolites: Principles of HERCULES

G Oeltzschner, MG Saleh, D Rimbault, M Mikkelsen… - Neuroimage, 2019 - Elsevier
Purpose To demonstrate the framework of a novel Hadamard-encoded spectral editing
approach for simultaneously detecting multiple low-concentration brain metabolites in vivo …

Effect of age on GABA+ and glutathione in a pediatric sample

MG Saleh, A Papantoni, M Mikkelsen… - American Journal …, 2020 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Gamma-aminobutyric acid (GABA) is the primary inhibitory
neurotransmitter in the human brain and is implicated in several neuropathologies …