Biofilms are surface-attached groups of microbial cells encased in an extracellular matrix
that are significantly less susceptible to antimicrobial agents than non-adherent, planktonic …

Bacterial biofilms are the basis of many persistent diseases. The persistence of these
infections is primarily attributed to the increased antibiotic resistance exhibited by the cells …

Antibiotic resistance is one of the greatest challenges of the twenty-first century. However,
the increasing understanding of bacterial pathogenesis and intercellular communication has …

The functional spectrum of a secretion system is defined by its substrates. Here we analyzed
the secretomes of Pseudomonas aeruginosa mutants altered in regulation of the Hcp …

Infections with Pseudomonas aeruginosa have become a concerning threat in hospital-
acquired infections and for cystic fibrosis patients. The major problem leading to high …

The type VI secretion system (T6SS) is a widespread molecular weapon deployed by many
Proteobacteria to target effectors/toxins into both eukaryotic and prokaryotic cells. We report …

Highlights•T6SS is a secretion system involved in the virulence of bacterial pathogens.•This
versatile weapon can target both prokaryotic and eukaryotic cells.•The T6SS tail/spike …

Plant pathogenic bacteria of the genus Xanthomonas cause a variety of diseases in
economically important monocotyledonous and dicotyledonous crop plants worldwide …

Protein secretion is a common property of pathogenic microbes. Gram-negative bacterial
pathogens use at least 6 distinct extracellular protein secretion systems to export proteins …

Background The availability of hundreds of bacterial genomes allowed a comparative
genomic study of the Type VI Secretion System (T6SS), recently discovered as being …