Effects of clozapine and risperidone antipsychotic drugs on the expression of CACNA1C and behavioral changes in rat 'Ketamine model of schizophrenia
Abstract Calcium Voltage-Gated Channel Subunit Alpha1 C (CACNA1C) is one of the most
important genes associated with schizophrenia. In this study, 45 male Wistar rats were …
important genes associated with schizophrenia. In this study, 45 male Wistar rats were …
[HTML][HTML] Mapping of c-Fos Expression in Rat Brain Sub/Regions Following Chronic Social Isolation: Effective Treatments of Olanzapine, Clozapine or Fluoxetine
A Stanisavljević Ilić, D Filipović - Pharmaceuticals, 2024 - mdpi.com
The c-Fos as a marker of cell activation is used to identify brain regions involved in stimuli
processing. This review summarizes a pattern of c-Fos immunoreactivity and the …
processing. This review summarizes a pattern of c-Fos immunoreactivity and the …
Clozapine prevented social interaction deficits and reduced c-Fos immunoreactivity expression in several brain areas of rats exposed to acute restraint stress
RP de Oliveira, JS de Andrade, M Spina, JV Chamon… - PLoS …, 2022 - journals.plos.org
In the present study, we evaluate the effect of acute restraint stress (15 min) of male Wistar
rats on social interaction measurements and c-Fos immunoreactivity (c-Fos-ir) expression, a …
rats on social interaction measurements and c-Fos immunoreactivity (c-Fos-ir) expression, a …
Combined Antagonism of 5-HT2 and NMDA Receptors Reduces the Aggression of Monoamine Oxidase a Knockout Mice
R Frau, A Pardu, S Godar, V Bini, M Bortolato - Pharmaceuticals, 2022 - mdpi.com
The enzyme monoamine oxidase A (MAOA) catalyzes the degradation of several
neurotransmitters, including serotonin. A large body of evidence has shown that genetic …
neurotransmitters, including serotonin. A large body of evidence has shown that genetic …
Adjunctive clozapine with bright light mitigates cognitive deficits by synaptic plasticity and neurogenesis in sub-chronic MK-801 treated mice
L Zhang, Y Zhou, Y Xie, Y Ying, Y Li, S Ye… - Pharmacology …, 2024 - Elsevier
Schizophrenia impacts about 1% of the global population, with clozapine (CLZ) being a
critical treatment for refractory cases despite its limitations in effectiveness and adverse …
critical treatment for refractory cases despite its limitations in effectiveness and adverse …