Metabolic phenotyping is an important tool in translational biomedical research. The
advanced analytical technologies commonly used for phenotyping, including mass …

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome
resistance to immune checkpoint inhibitors in patients with refractory melanoma; however …

Genome-wide association studies (GWASs) have identified genetic loci associated with the
risk of Alzheimer's disease (AD), but the molecular mechanisms by which they confer risk …

Background Patients with inflammatory bowel disease (IBD) treated with anti-TNF therapy
exhibit attenuated humoral immune responses to vaccination against SARS-CoV-2. The gut …

Background There is increasing interest in the bidirectional relationship existing between
the gut and brain and the effects of both oligofructose and 2'fucosyllactose to alter microbial …

Background and aims The gut microbiota is implicated in the pathogenesis of colorectal
cancer (CRC). We aimed to map the CRC mucosal microbiota and metabolome and define …

Finding early disease markers using non-invasive and widely available methods is essential
to develop a successful therapy for Alzheimer's Disease. Few studies to date have examined …

The pregnancy vaginal microbiome contributes to risk of preterm birth, the primary cause of
death in children under 5 years of age. Here we describe direct on-swab metabolic profiling …

Liquid chromatography–mass spectrometry (LC-MS) is a powerful and widely used
technique for measuring the abundance of chemical species in living systems. Its sensitivity …

This Perspective outlines recent progress and future directions for using machine learning
(ML), a data-driven method, to address critical questions in the design, synthesis …