Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …

Tissue-resident macrophages have been associated with important and diverse biological
processes such as native immunity, tissue homeostasis and angiogenesis during …

Haematopoietic stem cells (HSCs) emerge during embryogenesis and give rise to the adult
haematopoietic system. Understanding how early haematopoietic development occurs is of …

The generation of haematopoietic stem cells (HSCs) from human pluripotent stem cells
(hPSCs) will depend on the accurate recapitulation of embryonic haematopoiesis. In the …

Bone marrow endothelial cells (ECs) are essential for reconstitution of hematopoiesis, but
their role in self-renewal of long-term hematopoietic stem cells (LT-HSCs) is unknown. We …

Hematopoietic stem cells (HSCs) underlie the production of blood and immune cells for the
lifetime of an organism. In vertebrate embryos, HSCs arise from the unique …

The circulatory system is the first organ system to develop in the vertebrate embryo and is
critical throughout gestation for the delivery of oxygen and nutrients to, as well as removal of …

Definitive hematopoietic stem cells (HSCs) lie at the foundation of the adult hematopoietic
system and provide an organism throughout its life with all blood cell types. Several tissues …

Hematopoietic stem cells (HSCs) develop during embryogenesis in a complex process that
involves multiple anatomical sites. Once HSC precursors have been specified from …

Notch signaling has been shown over the past few decades to play fundamental roles in a
plethora of developmental processes in an evolutionarily conserved fashion. Notch …