Estrogen receptor β (ERβ) is closely related to breast cancer (BC) progression. Traditional
concepts regard ERβ as a tumor suppressor. As studies show the carcinogenic effect of …

Triple-negative breast cancer (TNBC) lacks estrogen receptor (ER) α, but the expression of
estrogen receptors ERβ and G protein-coupled estrogen receptor 1 (GPER-1) is able to …

Dysregulation of microRNAs (miRNAs) is associated with the occurrence and development
of breast cancer. In this research, we explored the involvement of miR-181a-5p in the …

Farnesyl-diphosphate farnesyltransferase 1 (FDFT1, squalene synthase), a membrane-
associated enzyme, synthesizes squalene via condensation of two molecules of farnesyl …

Upon the induction of DNA damage, the chromatin structure unwinds to allow access to
enzymes to catalyse the repair. The regulation of the winding and unwinding of chromatin …

MicroRNAs (miRNAs) are non‑coding RNAs (ncRNAs) that can post‑transcriptionally
suppress targeted genes. Dysregulated miRNAs are associated with a variety of diseases …

Simple Summary Endocrine therapy is a common treatment for estrogen-responsive breast
cancer, which is used to block the tumor growth-promoting effect of this hormone. The …

Breast cancer, a malignant tumor originating from mammary epithelial tissue, is the most
common cancer among women worldwide. Challenges facing the diagnosis and treatment …

Estrogen receptors (ERα and ERβ) are ligand-activated transcription factors that play
different roles in gene regulation and show both overlapping and specific tissue distribution …

P-element-induced wimpy testis (Piwi)-interacting RNAs (piRNAs) are a class of germline-
enriched small non-coding RNA that associate with Piwi family proteins and mostly induce …