Recent advances in human respiratory epithelium models for drug discovery

N Yaqub, G Wayne, M Birchall, W Song - Biotechnology Advances, 2022 - Elsevier
The respiratory epithelium is intimately associated with the pathophysiologies of highly
infectious viral contagions and chronic illnesses such as chronic obstructive pulmonary …

The yielding behaviour of human mucus

D Kavishvar, A Ramachandran - Advances in Colloid and Interface Science, 2023 - Elsevier
Mucus is a viscoelastic material with non-linear rheological properties such as yield stress of
the order of a few hundreds of millipascals to a few tens of pascals, due to a complex …

[HTML][HTML] Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19

C Tindle, MK Fuller, A Fonseca, S Taheri… - Elife, 2021 - elifesciences.org
Background: SARS-CoV-2, the virus responsible for COVID-19, causes widespread damage
in the lungs in the setting of an overzealous immune response whose origin remains …

[HTML][HTML] Rheological analysis of sputum from patients with chronic bronchial diseases

J Patarin, É Ghiringhelli, G Darsy, M Obamba… - Scientific reports, 2020 - nature.com
Bronchial diseases are characterised by the weak efficiency of mucus transport through the
lower airways, leading in some cases to the muco-obstruction of bronchi. It has been …

Novel analytical tools reveal that local synchronization of cilia coincides with tissue-scale metachronal waves in zebrafish multiciliated epithelia

C Ringers, S Bialonski, M Ege, A Solovev, JN Hansen… - Elife, 2023 - elifesciences.org
Motile cilia are hair-like cell extensions that beat periodically to generate fluid flow along
various epithelial tissues within the body. In dense multiciliated carpets, cilia were shown to …

[HTML][HTML] Strategies for measuring airway mucus and mucins

KR Atanasova, LR Reznikov - Respiratory Research, 2019 - Springer
Mucus secretion and mucociliary transport are essential defense mechanisms of the
airways. Deviations in mucus composition and secretion can impede mucociliary transport …

[HTML][HTML] Mucus, microbiomes and pulmonary disease

OW Meldrum, SH Chotirmall - Biomedicines, 2021 - mdpi.com
The respiratory tract harbors a stable and diverse microbial population within an
extracellular mucus layer. Mucus provides a formidable defense against infection and …

[HTML][HTML] The Cilialyzer–A freely available open-source software for the analysis of mucociliary activity in respiratory cells

M Schneiter, SA Tschanz, A Escher, L Müller… - Computer methods and …, 2023 - Elsevier
Abstract Background and Objective Primary ciliary dyskinesia (PCD) is a rare genetic
disorder causing a defective ciliary structure, which predominantly leads to an impaired …

Active mucus–cilia hydrodynamic coupling drives self-organization of human bronchial epithelium

E Loiseau, S Gsell, A Nommick, C Jomard, D Gras… - Nature Physics, 2020 - nature.com
The respiratory tract is protected by mucus, a complex fluid transported along the epithelial
surface by the coordinated beating of millions of microscopic cilia, hence the name of …

Lung epithelium damage in COPD–an unstoppable pathological event?

S Hadzic, CY Wu, S Avdeev, N Weissmann… - Cellular signalling, 2020 - Elsevier
Chronic obstructive pulmonary disease (COPD) is a common term for alveolar septal wall
destruction resulting in emphysema, and chronic bronchitis accompanied by conductive …