Recent advances in human respiratory epithelium models for drug discovery
The respiratory epithelium is intimately associated with the pathophysiologies of highly
infectious viral contagions and chronic illnesses such as chronic obstructive pulmonary …
infectious viral contagions and chronic illnesses such as chronic obstructive pulmonary …
The yielding behaviour of human mucus
D Kavishvar, A Ramachandran - Advances in Colloid and Interface Science, 2023 - Elsevier
Mucus is a viscoelastic material with non-linear rheological properties such as yield stress of
the order of a few hundreds of millipascals to a few tens of pascals, due to a complex …
the order of a few hundreds of millipascals to a few tens of pascals, due to a complex …
[HTML][HTML] Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19
C Tindle, MK Fuller, A Fonseca, S Taheri… - Elife, 2021 - elifesciences.org
Background: SARS-CoV-2, the virus responsible for COVID-19, causes widespread damage
in the lungs in the setting of an overzealous immune response whose origin remains …
in the lungs in the setting of an overzealous immune response whose origin remains …
[HTML][HTML] Rheological analysis of sputum from patients with chronic bronchial diseases
J Patarin, É Ghiringhelli, G Darsy, M Obamba… - Scientific reports, 2020 - nature.com
Bronchial diseases are characterised by the weak efficiency of mucus transport through the
lower airways, leading in some cases to the muco-obstruction of bronchi. It has been …
lower airways, leading in some cases to the muco-obstruction of bronchi. It has been …
Novel analytical tools reveal that local synchronization of cilia coincides with tissue-scale metachronal waves in zebrafish multiciliated epithelia
Motile cilia are hair-like cell extensions that beat periodically to generate fluid flow along
various epithelial tissues within the body. In dense multiciliated carpets, cilia were shown to …
various epithelial tissues within the body. In dense multiciliated carpets, cilia were shown to …
[HTML][HTML] Strategies for measuring airway mucus and mucins
KR Atanasova, LR Reznikov - Respiratory Research, 2019 - Springer
Mucus secretion and mucociliary transport are essential defense mechanisms of the
airways. Deviations in mucus composition and secretion can impede mucociliary transport …
airways. Deviations in mucus composition and secretion can impede mucociliary transport …
[HTML][HTML] Mucus, microbiomes and pulmonary disease
OW Meldrum, SH Chotirmall - Biomedicines, 2021 - mdpi.com
The respiratory tract harbors a stable and diverse microbial population within an
extracellular mucus layer. Mucus provides a formidable defense against infection and …
extracellular mucus layer. Mucus provides a formidable defense against infection and …
[HTML][HTML] The Cilialyzer–A freely available open-source software for the analysis of mucociliary activity in respiratory cells
M Schneiter, SA Tschanz, A Escher, L Müller… - Computer methods and …, 2023 - Elsevier
Abstract Background and Objective Primary ciliary dyskinesia (PCD) is a rare genetic
disorder causing a defective ciliary structure, which predominantly leads to an impaired …
disorder causing a defective ciliary structure, which predominantly leads to an impaired …
Active mucus–cilia hydrodynamic coupling drives self-organization of human bronchial epithelium
The respiratory tract is protected by mucus, a complex fluid transported along the epithelial
surface by the coordinated beating of millions of microscopic cilia, hence the name of …
surface by the coordinated beating of millions of microscopic cilia, hence the name of …
Lung epithelium damage in COPD–an unstoppable pathological event?
Chronic obstructive pulmonary disease (COPD) is a common term for alveolar septal wall
destruction resulting in emphysema, and chronic bronchitis accompanied by conductive …
destruction resulting in emphysema, and chronic bronchitis accompanied by conductive …