The public health importance of Barrett's oesophagus lies in its association with
oesophageal adenocarcinoma. The incidence of oesophageal adenocarcinoma has risen at …

Background Clinical progression of colorectal cancers (CRC) may occur in parallel with
distinctive signaling alterations. We designed multidirectional analyses integrating …

All cancers are believed to arise by dynamic, stochastic somatic genomic evolution with
genome instability, generation of diversity, and selection of genomic alterations that underlie …

Na+/H+ exchangers (NHEs) are expressed in virtually all human tissues and organs. Two
major tasks of those NHE isoforms that are located in plasma membranes are cell volume …

Background Barrett's esophagus is a premalignant condition whereby the normal stratified
squamous esophageal epithelium undergoes a transdifferentiation program resulting in a …

Columnar metaplasia of the esophagus is the main risk factor for esophageal
adenocarcinoma. There is a lack of evidence to demonstrate that esophageal progenitors …

Esophageal cancer (ESCA) is the seventh most frequent and deadly neoplasm. Due to the
lack of early diagnosis and high invasion/metastasis, the prognosis of ESCA remains very …

Objective Barrett's oesophagus is a premalignant disease associated with oesophageal
adenocarcinoma. The major goal of this study was to determine the mechanism responsible …

Kinase domains are the type of protein domain most commonly found in genes associated
with tumorigenesis. Because of this, the human kinome (the protein kinase component of the …

Background Barrett's esophagus (BE) is known to progress to esophageal adenocarcinoma
in a setting of chronic inflammation. Toll-like receptor (TLR) 4 has been linked to …