Nucleocytoplasmic transport is an essential process in eukaryotes. The molecular
mechanisms underlying nuclear transport that involve the nuclear transport receptor, small …

Importin α performs the indispensable role of ferrying proteins from the cytoplasm into the
nucleus with a transport carrier, importin β1. Mammalian cells from mouse or human contain …

Nuclear transport receptors of the karyopherin superfamily of proteins transport
macromolecules from one compartment to the other and are critical for both cell physiology …

In recent years, Karyopherin α 2 (KPNA2) has emerged as a potential biomarker in multiple
cancer forms. The aberrant high levels observed in cancer tissue have been associated with …

After two decades of stardom, one would think that β‐catenin has revealed all of its most
intimate details. Yet the essence of its duality has remained mysterious—how can a single …

Apoptosis is a mode of regulated cell death that is indispensable for the morphogenesis,
development and homeostasis of multicellular organisms. Caspases are cysteine …

The outbreaks of hepatitis-hydropericardium syndrome (HPS) caused by the highly
pathogenic serotype 4 fowl adenovirus (FAdV-4) have caused a huge economic loss to the …

Importin α4, which is encoded by the Kpna4 gene, is a well-characterized nuclear-
cytoplasmic transport factor known to mediate transport of transcription factors including NF …

7 Nuclear Transport Inhibitors Page 1 7 Nuclear Transport Inhibitors CHERYL LONDON* Tufts
University, North Grafton, Massachusetts, USA Introduction: Regulation of Nuclear Transport The …

The development of colorectal cancer (CRC) is often sporadic, but its etiology is
multifactorial. Chemoresistance of CRC leads to tumor recurrence and poor prognosis in …