The immunology of multiple sclerosis

KE Attfield, LT Jensen, M Kaufmann… - Nature Reviews …, 2022 - nature.com
Our incomplete understanding of the causes and pathways involved in the onset and
progression of multiple sclerosis (MS) limits our ability to effectively treat this complex …

The current and future perspectives of postbiotics

B Liang, D Xing - Probiotics and Antimicrobial Proteins, 2023 - Springer
With the emphasis on intestinal health, probiotics have exploded into a vast market potential.
However, new scientific evidence points out that the beneficial health benefits of probiotics …

Microbiome and metabolome features in inflammatory bowel disease via multi-omics integration analyses across cohorts

L Ning, YL Zhou, H Sun, Y Zhang, C Shen… - Nature …, 2023 - nature.com
The perturbations of the gut microbiota and metabolites are closely associated with the
progression of inflammatory bowel disease (IBD). However, inconsistent findings across …

The gut microbiota in multiple sclerosis varies with disease activity

F Thirion, F Sellebjerg, Y Fan, L Lyu, TH Hansen… - Genome medicine, 2023 - Springer
Background Multiple sclerosis is a chronic immune-mediated disease of the brain and spinal
cord resulting in physical and cognitive impairment in young adults. It is hypothesized that a …

The gut-brain axis in multiple sclerosis. Is its dysfunction a pathological trigger or a consequence of the disease?

B Parodi, N Kerlero de Rosbo - Frontiers in immunology, 2021 - frontiersin.org
A large and expending body of evidence indicates that the gut-brain axis likely plays a
crucial role in neurological diseases, including multiple sclerosis (MS). As a whole, the gut …

Adlercreutzia equolifaciens Is an Anti-Inflammatory Commensal Bacterium with Decreased Abundance in Gut Microbiota of Patients with Metabolic Liver Disease

FP Oñate, C Chamignon, SD Burz, N Lapaque… - International Journal of …, 2023 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) affects about 20–40% of the adult population in
high-income countries and is now a leading indication for liver transplantation and can lead …

Obesity induced gut dysbiosis contributes to disease severity in an animal model of multiple sclerosis

SK Shahi, S Ghimire, P Lehman… - Frontiers in …, 2022 - frontiersin.org
Background Multiple sclerosis (MS) is an inflammatory and demyelinating disease of the
CNS. The etiology of MS is complex, and results from the interaction of multiple …

Dietary isoflavones alter gut microbiota and lipopolysaccharide biosynthesis to reduce inflammation

S Ghimire, NM Cady, P Lehman, SR Peterson… - Gut …, 2022 - Taylor & Francis
The etiopathogenesis of multiple sclerosis (MS) is strongly affected by environmental factors
such as diet and the gut microbiota. An isoflavone-rich (ISO) diet was previously shown to …

Acidic natural deep eutectic solvents as dual solvents and catalysts for the solubilization and deglycosylation of soybean isoflavone extracts: Genistin as a model …

J Chen, Y Ni, P Zhang, X Liang, S Fang - Food Chemistry, 2023 - Elsevier
This study investigated the possibility of using green solvent natural deep eutectic solvents
(NADESs) as dual solvent-catalysts for the solubilization and deglycosylation of soybean …

Under the influence: environmental factors as modulators of neuroinflammation through the IL-10/IL-10R axis

E Bugbee, AA Wang, JL Gommerman - Frontiers in Immunology, 2023 - frontiersin.org
The IL-10/IL-10 receptor (IL-10R) axis plays an important role in attenuating
neuroinflammation in animal models of Multiple Sclerosis (MS) and increased IL-10 has …