Long non-coding RNA in the pathogenesis of cancers

Y Chi, D Wang, J Wang, W Yu, J Yang - Cells, 2019 - mdpi.com
The incidence and mortality rate of cancer has been quickly increasing in the past decades.
At present, cancer has become the leading cause of death worldwide. Most of the cancers …

Long noncoding RNAs as biomarkers in cancer

L Bolha, M Ravnik-Glavač, D Glavač - Disease markers, 2017 - Wiley Online Library
Long noncoding RNAs (lncRNAs) are a relatively well‐characterized class of noncoding
RNA (ncRNA) molecules, involved in the regulation of various cell processes, including …

Retracted: LncRNA HOTAIR influences cell growth, migration, invasion, and apoptosis via the miR‐20a‐5p/HMGA2 axis in breast cancer

W Zhao, D Geng, S Li, Z Chen, M Sun - Cancer medicine, 2018 - Wiley Online Library
To study the regulatory effect of lnc RNA HOTAIR/miR‐20a‐5p/HMGA 2 axis on breast
cancer (BC) cell growth, cell mobility, invasiveness, and apoptosis. The microarray data of …

Breast cancer: current molecular therapeutic targets and new players

S Nagini - Anti-Cancer Agents in Medicinal Chemistry …, 2017 - ingentaconnect.com
Breast cancer is the most common cancer and the most frequent cause of cancer death
among women worldwide. Breast cancer is a complex, heterogeneous disease classified …

HOTAIR: an oncogenic long non-coding RNA in human cancer

Q Tang, SS Hann - Cellular Physiology and Biochemistry, 2018 - karger.com
Abstract Long non-coding RNAs (LncRNAs) represent a novel class of noncoding RNAs that
are longer than 200 nucleotides without protein-coding potential and function as novel …

LncRNA HOTAIR: A master regulator of chromatin dynamics and cancer

A Bhan, SS Mandal - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2015 - Elsevier
Non-coding RNAs (ncRNAs) are emerging classes of regulatory RNA that play key roles in
various cellular and physiological processes such as in gene regulation, chromatin …

LncRNA HOTAIR enhances ER signaling and confers tamoxifen resistance in breast cancer

X Xue, YA Yang, A Zhang, KW Fong, J Kim, B Song… - Oncogene, 2016 - nature.com
Tamoxifen, an estrogen receptor (ER) antagonist, is the mainstay treatment of breast cancer
and the development of resistance represents a major obstacle for a cure. Although long …

LncRNAs in breast cancer: a link to future approaches

N Sideris, P Dama, S Bayraktar, T Stiff… - Cancer gene …, 2022 - nature.com
Breast cancer affects millions of women each year. Despite recent advances in targeted
treatments breast cancer remains a significant threat to women's health. In recent years the …

[HTML][HTML] HOTAIR: an oncogenic long non-coding RNA in different cancers

M Hajjari, A Salavaty - Cancer biology & medicine, 2015 - ncbi.nlm.nih.gov
Long non-coding RNAs (lncRNAs) refer to a group of RNAs that are usually more than 200
nucleotides and are not involved in protein generation. Instead, lncRNAs are involved in …

LncRNA HOTAIR enhances the androgen-receptor-mediated transcriptional program and drives castration-resistant prostate cancer

A Zhang, JC Zhao, J Kim, K Fong, YA Yang… - Cell reports, 2015 - cell.com
Understanding the mechanisms of androgen receptor (AR) activation in the milieu of low
androgen is critical to effective treatment of castration-resistant prostate cancer (CRPC) …