Applying a high voltage to a liquid passing through a capillary disintegrates the liquid
meniscus to generate a fine spray of charged droplets. As the droplets evaporate, polar …

Small molecule drug discovery has been propelled by the continual development of novel
scientific methodologies to occasion therapeutic advances. Although established …

The Electrospray Ionization (ESI) is a soft ionization technique extensively used for
production of gas phase ions (without fragmentation) of thermally labile large …

When non-mass spectrometrists are talking about mass spectrometry it rather often sounds
as if they were telling a story out of Poe's Tales of Mystery and Imagi-tion. Indeed, mass …

This review provides a broad overview of recent Fourier transform ion cyclotron resonance
(FTICR) applications and technological developments relevant to the field of proteomics …

The origin of the extent of charging and the mechanism by which multiply charged ions are
formed in electrospray ionization have been hotly debated for over a decade. Many factors …

Native mass spectrometry (MS) is aimed at preserving and determining the native structure,
composition, and stoichiometry of biomolecules and their complexes from solution after they …

Top-down proteomics has improved over the past decade despite the significant challenges
presented by the analysis of large protein ions. Here, the detection of these high mass …

We present measurements of the distributions of droplet size and charge along with, for
selected droplets, the variation of droplet size and charge with time for electrosprays of …

The origin of asymmetric charge and mass partitioning observed for gas-phase dissociation
of multiply charged macromolecular complexes has been hotly debated. These experiments …