As a result of natural selection driven by severe forms of malaria, 1 in 6 humans in the world,
more than 1 billion people, are affected by red cell abnormalities, making them the most …

Remarkable progress has been made in understanding effector molecules of small GTPase
Rho, especially Rho-associated kinase (Rho-kinase/ROK/ROCK), in the past 5 years. Rho …

Erythropoiesis is the process by which nucleated erythroid progenitors proliferate and
differentiate to generate, every second, millions of nonnucleated red cells with their unique …

CHIP28 is a 28-kDa integral membrane protein with similarities to membrane channels and
is found in erythrocytes and renal tubules. A cDNA for CHIP28 was isolated from human fetal …

The ERM family members, ezrin, radixin, and moesin, localizing just beneath the plasma
membranes, are thought to be involved in the actin filament/plasma membrane association …

CD44 has been identified as a membrane-binding partner for ezrin/radixin/moesin (ERM)
proteins, plasma membrane/actin filament cross-linkers. ERM proteins, however, are not …

Polarized epithelial cells play fundamental roles in the ontogeny and function of a variety of
tissues and organs in mammals. The morphogenesis of a sheet of polarized epithelial cells …

Studies during the last three decades have enabled the development of detailed molecular
insights into the structural basis of altered function in various inherited red cell membrane …

Proteins at the boundary between the cytoskeleton and the plasma membrane control cell
shape, delimit specialized membrane domains, and stabilize attachments to other cells and …

The ERM proteins, ezrin, radixin, and moesin, are involved in the actin filament/plasma
membrane interaction as cross-linkers. CD44 has been identified as one of the major …