Humans require a plethora of higher cognitive skills to perform executive functions, such as
reasoning, planning, language and social interactions, which are regulated predominantly …

The prefrontal cortex (PFC) is involved in working memory and self-regulatory and goal-
directed behaviors and displays remarkable structural and functional plasticity over the life …

Normal ageing is associated with impairments in cognitive function, including memory.
These impairments are linked, not to a loss of neurons in the forebrain, but to specific and …

A comparative and integrated account is provided of the evidence that implicates
frontostriatal systems in neurodegenerative and neuropsychiatric disorders. Specifically, we …

Given the rapid rate of population aging and the increased incidence of cognitive decline
and neurodegenerative diseases with advanced age, it is important to ascertain the …

Cognitive deficits in schizophrenia are among the core symptoms of the disease, correlate
with functional outcome, and are not well treated with current antipsychotic therapies. In …

The brain noradrenergic system is thought to facilitate neuronal processes that promote
behavioral activation, alertness, and attention. One region in which norepinephrine may …

Brain networks that engage the hippocampus and prefrontal cortex are central for enabling
effective interactions with our environment. Some of the cognitive processes that these …

The prefrontal cortex (PFC) plays an important role in the integration of cognitive and
affective behavior and regulating autonomic and neuroendocrine functions. This region of …

Patterns of individual differences in cognition have been studied empirically and
systematically in the last decade, but causes and consequences of this variation are still …