Accelerating crop genetic gains with genomic selection

KP Voss-Fels, M Cooper, BJ Hayes - Theoretical and Applied Genetics, 2019 - Springer
Key message Genomic prediction based on additive genetic effects can accelerate genetic
gain. There are opportunities for further improvement by including non-additive effects that …

Ecological genomics of local adaptation

O Savolainen, M Lascoux, J Merilä - Nature Reviews Genetics, 2013 - nature.com
It is increasingly important to improve our understanding of the genetic basis of local
adaptation because of its relevance to climate change, crop and animal production, and …

Functional mapping and annotation of genetic associations with FUMA

K Watanabe, E Taskesen, A Van Bochoven… - Nature …, 2017 - nature.com
A main challenge in genome-wide association studies (GWAS) is to pinpoint possible causal
variants. Results from GWAS typically do not directly translate into causal variants because …

Breeding crops for drought-affected environments and improved climate resilience

M Cooper, CD Messina - The Plant Cell, 2023 - academic.oup.com
Breeding climate-resilient crops with improved levels of abiotic and biotic stress resistance
as a response to climate change presents both opportunities and challenges. Applying the …

Enhancing genetic gain through genomic selection: from livestock to plants

Y Xu, X Liu, J Fu, H Wang, J Wang, C Huang… - Plant …, 2020 - cell.com
Although long-term genetic gain has been achieved through increasing use of modern
breeding methods and technologies, the rate of genetic gain needs to be accelerated to …

Promises and challenges of big data computing in health sciences

T Huang, L Lan, X Fang, P An, J Min, F Wang - Big Data Research, 2015 - Elsevier
With the development of smart devices and cloud computing, more and more public health
data can be collected from various sources and can be analyzed in an unprecedented way …

Predicting the future of plant breeding: complementing empirical evaluation with genetic prediction

M Cooper, CD Messina, D Podlich… - Crop and Pasture …, 2014 - CSIRO Publishing
For the foreseeable future, plant breeding methodology will continue to unfold as a practical
application of the scaling of quantitative biology. These efforts to increase the effective scale …

The genetic epidemiology of substance use disorder: A review

EC Prom-Wormley, J Ebejer, DM Dick… - Drug and alcohol …, 2017 - Elsevier
Background Substance use disorder (SUD) remains a significant public health issue. A
greater understanding of how genes and environment interact to regulate phenotypes …

Integrating crop growth models with whole genome prediction through approximate Bayesian computation

F Technow, CD Messina, LR Totir, M Cooper - PloS one, 2015 - journals.plos.org
Genomic selection, enabled by whole genome prediction (WGP) methods, is revolutionizing
plant breeding. Existing WGP methods have been shown to deliver accurate predictions in …

Leveraging biological insight and environmental variation to improve phenotypic prediction: Integrating crop growth models (CGM) with whole genome prediction …

CD Messina, F Technow, T Tang, R Totir, C Gho… - European Journal of …, 2018 - Elsevier
A successful strategy for prediction of crop yield that accounts for the effects of genotype,
environment and their interactions with management will create many opportunities for …