Disease-modifying drugs in osteoarthritis: current understanding and future therapeutics
Introduction: Osteoarthritis (OA) is a leading cause of pain and disability among adults with a
current prevalence of around 15% and a predicted prevalence of 35% in 2030 for …
current prevalence of around 15% and a predicted prevalence of 35% in 2030 for …
The efficacy and safety of disease-modifying osteoarthritis drugs for knee and hip osteoarthritis—a systematic review and network meta-analysis
W Yang, C Sun, SQ He, JY Chen, Y Wang… - Journal of General …, 2021 - Springer
Background Osteoarthritis (OA) is common and burdensome for patients and health care
systems. Our study purpose was to evaluate the long-term efficacy and safety of DMOADs in …
systems. Our study purpose was to evaluate the long-term efficacy and safety of DMOADs in …
[HTML][HTML] Evolution of semi-quantitative whole joint assessment of knee OA: MOAKS (MRI Osteoarthritis Knee Score)
OBJECTIVE: In an effort to evolve semi-quantitative scoring methods based upon limitations
identified in existing tools, integrating expert readers' experience with all available scoring …
identified in existing tools, integrating expert readers' experience with all available scoring …
[HTML][HTML] EULAR recommendations for the use of imaging in the clinical management of peripheral joint osteoarthritis
G Sakellariou, PG Conaghan, W Zhang… - Annals of the …, 2017 - ard.bmj.com
The increased information provided by modern imaging has led to its more extensive use.
Our aim was to develop evidence-based recommendations for the use of imaging in the …
Our aim was to develop evidence-based recommendations for the use of imaging in the …
Toward classification criteria for early osteoarthritis of the knee
Objective To propose draft classification criteria for early stage osteoarthritis (OA) of the knee
for use in a primary care setting. Methods A group of basic scientists, physician-scientists …
for use in a primary care setting. Methods A group of basic scientists, physician-scientists …
Intraarticular sprifermin (recombinant human fibroblast growth factor 18) in knee osteoarthritis: a randomized, double‐blind, placebo‐controlled trial
LS Lohmander, S Hellot, D Dreher… - Arthritis & …, 2014 - Wiley Online Library
Objective To evaluate the efficacy and safety of intraarticular sprifermin (recombinant human
fibroblast growth factor 18) in the treatment of symptomatic knee osteoarthritis (OA). Methods …
fibroblast growth factor 18) in the treatment of symptomatic knee osteoarthritis (OA). Methods …
Clinical and radiographic comparison of a single LP-PRP injection, a single hyaluronic acid injection and daily NSAID administration with a 52-week follow-up: a …
D Buendía-López, M Medina-Quirós… - Journal of Orthopaedics …, 2018 - Springer
Background Knee osteoarthritis (OA) is a disease with a high prevalence in the adult
population. Nonsteroidal anti-inflammatory drugs (NSAID) or intra-articular injections …
population. Nonsteroidal anti-inflammatory drugs (NSAID) or intra-articular injections …
Biomarkers for osteoarthritis: current position and steps towards further validation
Historically disease knowledge development and treatment innovation in osteoarthritis (OA)
has been considered to be slow. One of the many reasons purported as responsible for this …
has been considered to be slow. One of the many reasons purported as responsible for this …
Lorecivivint, a novel Intraarticular CDC‐like kinase 2 and dual‐specificity tyrosine phosphorylation‐regulated kinase 1A inhibitor and Wnt pathway modulator for the …
Y Yazici, TE McAlindon, A Gibofsky… - Arthritis & …, 2020 - Wiley Online Library
Objective To assess the safety and efficacy of a novel Wnt pathway modulator, lorecivivint
(SM 04690), for treating pain and inhibiting structural progression in moderately to severely …
(SM 04690), for treating pain and inhibiting structural progression in moderately to severely …
Lateral wedge insoles for medial knee osteoarthritis: 12 month randomised controlled trial
KL Bennell, KA Bowles, C Payne, F Cicuttini… - Bmj, 2011 - bmj.com
Objective To assess the effect of lateral wedge insoles compared with flat control insoles on
improving symptoms and slowing structural disease progression in medial knee …
improving symptoms and slowing structural disease progression in medial knee …