Neurohumoral control of sinoatrial node activity and heart rate: insight from experimental models and findings from humans
The sinoatrial node is perhaps one of the most important tissues in the entire body: it is the
natural pacemaker of the heart, making it responsible for initiating each-and-every normal …
natural pacemaker of the heart, making it responsible for initiating each-and-every normal …
Guidelines for assessment of cardiac electrophysiology and arrhythmias in small animals
Cardiac arrhythmias are a major cause of morbidity and mortality worldwide. Although
recent advances in cell-based models, including human-induced pluripotent stem cell …
recent advances in cell-based models, including human-induced pluripotent stem cell …
Transcriptomic profiling of the developing cardiac conduction system at single-cell resolution
Rationale: The cardiac conduction system (CCS) consists of distinct components including
the sinoatrial node, atrioventricular node, His bundle, bundle branches, and Purkinje fibers …
the sinoatrial node, atrioventricular node, His bundle, bundle branches, and Purkinje fibers …
Synchronized cardiac impulses emerge from heterogeneous local calcium signals within and among cells of pacemaker tissue
R Bychkov, M Juhaszova, K Tsutsui, C Coletta… - Clinical …, 2020 - jacc.org
Objectives This study sought to identify subcellular Ca2+ signals within and among cells
comprising the sinoatrial node (SAN) tissue. Background The current paradigm of SAN …
comprising the sinoatrial node (SAN) tissue. Background The current paradigm of SAN …
Optical stimulation of cardiac cells with a polymer-supported silicon nanowire matrix
R Parameswaran, K Koehler… - Proceedings of the …, 2019 - National Acad Sciences
Electronic pacemakers can treat electrical conduction disorders in hearts; however, they are
invasive, bulky, and linked to increased incidence of infection at the tissue–device interface …
invasive, bulky, and linked to increased incidence of infection at the tissue–device interface …
Mechanisms of sinoatrial node dysfunction in heart failure with preserved ejection fraction
Background: The ability to increase heart rate during exercise and other stressors is a key
homeostatic feature of the sinoatrial node (SAN). When the physiological heart rate …
homeostatic feature of the sinoatrial node (SAN). When the physiological heart rate …
What makes the sinoatrial node tick? A question not for the faint of heart
L Donald, EG Lakatta - Philosophical Transactions of the …, 2023 - royalsocietypublishing.org
Even before the sinoatrial node (SAN) was discovered, cardiovascular science was
engaged in an active investigation of when and why the heart would beat. After the …
engaged in an active investigation of when and why the heart would beat. After the …
Pharmacologic approach to sinoatrial node dysfunction
P Mesirca, VV Fedorov, TJ Hund… - Annual review of …, 2021 - annualreviews.org
The spontaneous activity of the sinoatrial node initiates the heartbeat. Sino-atrial node
dysfunction (SND) and sick sinoatrial (sick sinus) syndrome are caused by the heart's …
dysfunction (SND) and sick sinoatrial (sick sinus) syndrome are caused by the heart's …
Genetic complexity of sinoatrial node dysfunction
The pacemaker cells of the cardiac sinoatrial node (SAN) are essential for normal cardiac
automaticity. Dysfunction in cardiac pacemaking results in human sinoatrial node …
automaticity. Dysfunction in cardiac pacemaking results in human sinoatrial node …
Silencing miR-370-3p rescues funny current and sinus node function in heart failure
Bradyarrhythmias are an important cause of mortality in heart failure and previous studies
indicate a mechanistic role for electrical remodelling of the key pacemaking ion channel …
indicate a mechanistic role for electrical remodelling of the key pacemaking ion channel …