Sulfonyl fluoride electrophiles have found significant utility as reactive probes in chemical
biology and molecular pharmacology. As warheads they possess the right balance of …

In recent years, members of the protein kinase family have been discovered at an
accelerated pace. Most were first described, not through the traditional biochemical …

EGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis.
Following ligand binding, EGFR stimulates downstream cell signaling cascades that …

Growth factors, a diverse group of polypeptides that modify cell proliferation, constitute a
distinct subgroup in endocrinology. The biology of these factors differs somewhat from …

A large number of serum growth factors stimulate cellular mitogenesis by interaction with a
family of cell-surface receptors that possess an intrinsic, ligand-sensitive, protein tyrosine …

A mild, efficient synthesis of sulfonyl fluorides from aryl and heteroaryl bromides utilizing
palladium catalysis is described. The process involves the initial palladium-catalyzed …

Laboratory studies that led to the development of epidermal growth factor receptor (EGFR)
inhibitors indicated that such inhibitors would be effective when given to patients with …

The study of the various protein kinases reveals that, despite their considerably diversity,
they have evolved from a common origin. Eleven conserved subdomains have been …

The kinase activity of human p34cdc2 is negatively regulated by phosphorylation at Thr-14
and Tyr-15. These residues lie within the putative nucleotide binding domain of p34cdc2. It …

Ijpidermal growth factor (EGF) is a polypeptide growth factor of 53 amino acidresidues
(Carpenter & Cohen, 1979), which mediates its biological responses by binding to and …