Aging constitutes the key risk factor for age‐related diseases such as cancer and
cardiovascular and neurodegenerative disorders. Human longevity and healthy aging are …

The objectives of this article are to facilitate deeper research and promote better policy
analysis for healthy aging with sound policy and intervention programs. Toward these …

Over a century ago, the zoologist Emile Maupas first identified the nematode, Rhabditis
elegans, in the soil in Algiers. Subsequent work and phylogenic studies renamed the …

Several pathologies such as neurodegeneration and cancer are associated with aging,
which is affected by many genetic and environmental factors. Healthy aging conceives …

Only two genome-wide significant loci associated with longevity have been identified so far,
probably because of insufficient sample sizes of centenarians, whose genomes may harbor …

Decline in biological resilience (ability to recover) is a key manifestation of aging that
contributes to increase in vulnerability to death with age eventually limiting longevity even in …

Hydra's unlimited life span has long attracted attention from natural scientists. The reason for
that phenomenon is the indefinite self-renewal capacity of its stem cells. The underlying …

Cholesterol homeostasis is crucial for cellular function and organismal health. The key
regulator for the cholesterol biosynthesis is sterol-regulatory element binding protein …

It was proposed that resveratrol, a polyphenolic antioxidant and a calorie restriction mimetic
could promote longevity but subsequent studies could not prove this. The original proposal …

After a brief introduction to the background, significance and unique features of the
centenarian population in China, we describe the Chinese Longitudinal Healthy Longevity …