Long live FOXO: unraveling the role of FOXO proteins in aging and longevity
Aging constitutes the key risk factor for age‐related diseases such as cancer and
cardiovascular and neurodegenerative disorders. Human longevity and healthy aging are …
cardiovascular and neurodegenerative disorders. Human longevity and healthy aging are …
Toward deeper research and better policy for healthy aging–using the unique data of Chinese longitudinal healthy longevity survey
Y Zeng - China economic journal, 2012 - Taylor & Francis
The objectives of this article are to facilitate deeper research and promote better policy
analysis for healthy aging with sound policy and intervention programs. Toward these …
analysis for healthy aging with sound policy and intervention programs. Toward these …
Using C. elegans for aging research
HA Tissenbaum - Invertebrate reproduction & development, 2015 - Taylor & Francis
Over a century ago, the zoologist Emile Maupas first identified the nematode, Rhabditis
elegans, in the soil in Algiers. Subsequent work and phylogenic studies renamed the …
elegans, in the soil in Algiers. Subsequent work and phylogenic studies renamed the …
FOXO transcriptional factors and long‐term living
Several pathologies such as neurodegeneration and cancer are associated with aging,
which is affected by many genetic and environmental factors. Healthy aging conceives …
which is affected by many genetic and environmental factors. Healthy aging conceives …
Novel loci and pathways significantly associated with longevity
Only two genome-wide significant loci associated with longevity have been identified so far,
probably because of insufficient sample sizes of centenarians, whose genomes may harbor …
probably because of insufficient sample sizes of centenarians, whose genomes may harbor …
[HTML][HTML] Decline in biological resilience as key manifestation of aging: Potential mechanisms and role in health and longevity
Decline in biological resilience (ability to recover) is a key manifestation of aging that
contributes to increase in vulnerability to death with age eventually limiting longevity even in …
contributes to increase in vulnerability to death with age eventually limiting longevity even in …
FoxO is a critical regulator of stem cell maintenance in immortal Hydra
AM Boehm, K Khalturin… - Proceedings of the …, 2012 - National Acad Sciences
Hydra's unlimited life span has long attracted attention from natural scientists. The reason for
that phenomenon is the indefinite self-renewal capacity of its stem cells. The underlying …
that phenomenon is the indefinite self-renewal capacity of its stem cells. The underlying …
Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6 [S]
Cholesterol homeostasis is crucial for cellular function and organismal health. The key
regulator for the cholesterol biosynthesis is sterol-regulatory element binding protein …
regulator for the cholesterol biosynthesis is sterol-regulatory element binding protein …
[Retracted] Antiaging Properties of a Grape‐Derived Antioxidant Are Regulated by Mitochondrial Balance of Fusion and Fission Leading to Mitophagy Triggered by a …
S Das, G Mitrovsky, HR Vasanthi… - Oxidative medicine and …, 2014 - Wiley Online Library
It was proposed that resveratrol, a polyphenolic antioxidant and a calorie restriction mimetic
could promote longevity but subsequent studies could not prove this. The original proposal …
could promote longevity but subsequent studies could not prove this. The original proposal …
Demographics, phenotypic health characteristics and genetic analysis of centenarians in China
After a brief introduction to the background, significance and unique features of the
centenarian population in China, we describe the Chinese Longitudinal Healthy Longevity …
centenarian population in China, we describe the Chinese Longitudinal Healthy Longevity …