Entry into mitosis is triggered by the activation of cyclin‐dependent kinase 1 (Cdk1). This
simple reaction rapidly and irreversibly sets the cell up for division. Even though the core …

Cell division is a phenomenon that is encountered in all cells in nature. While normal cell
division results in proliferation in single-celled organisms, and development and repair in …

Sex determination and differentiation is a complex process regulated by multiple factors,
including factors from the germline or surrounding somatic tissue. In zebrafish, sex …

Cyclin-dependent kinases (CDKs) require the binding to a regulatory subunit to acquire
enzymatic activity, and cyclins are the canonical CDK activators. However, there are specific …

Successful completion of the cell cycle relies on the precise activation and inactivation of
cyclin-dependent kinases (Cdks) whose activity is mainly regulated by binding to cyclins …

Although several studies have suggested that the functions of heterochromatin regulators
may be regulated by post-translational modifications during cell cycle progression …

Cell cycle progression is regulated by cyclin-dependent kinases (CDKs), whose activation
requires the binding of regulatory subunits named cyclins. RINGO/Speedy A is a mammalian …

Breast cancer is the second most common cancer worldwide and the most common cancer
among women, excluding non-melanoma skin cancers. The most common subtype of breast …

Background CD4+ T cells are critically important in HIV infection, being both the primary
cells infected by HIV and likely playing a direct or indirect role in helping control virus …

Advances in genetic screening technology have expanded the toolkit for systematic
perturbation of gene function. While the CRISPR-Cas9 system robustly probes genetic loss …