Mechanisms of endogenous neuroprotective effects of astrocytes in brain injury

MA Bylicky, GP Mueller, RM Day - Oxidative medicine and …, 2018 - Wiley Online Library
Astrocytes, once believed to serve only as “glue” for the structural support of neurons, have
been demonstrated to serve critical functions for the maintenance and protection of neurons …

The potential for animal models to provide insight into mild traumatic brain injury: translational challenges and strategies

SR Shultz, SJ McDonald, CV Haar, A Meconi… - Neuroscience & …, 2017 - Elsevier
Mild traumatic brain injury (mTBI) is a common health problem. There is tremendous
variability and heterogeneity in human mTBI, including mechanisms of injury, biomechanical …

Tractography methods and findings in brain tumors and traumatic brain injury

FC Yeh, A Irimia, DC de Almeida Bastos, AJ Golby - Neuroimage, 2021 - Elsevier
White matter fiber tracking using diffusion magnetic resonance imaging (dMRI) provides a
noninvasive approach to map brain connections, but improving anatomical accuracy has …

Impaired glymphatic function in the early stages of disease in a TDP-43 mouse model of amyotrophic lateral sclerosis

A Zamani, AK Walker, B Rollo, KL Ayers… - Translational …, 2022 - Springer
Background Multiple lines of evidence suggest possible impairment of the glymphatic
system in amyotrophic lateral sclerosis (ALS). To investigate this, we used in vivo magnetic …

Affective, neurocognitive and psychosocial disorders associated with traumatic brain injury and post-traumatic epilepsy

BD Semple, A Zamani, G Rayner, SR Shultz… - Neurobiology of …, 2019 - Elsevier
Survivors of traumatic brain injury (TBI) often develop chronic neurological, neurocognitive,
psychological, and psychosocial deficits that can have a profound impact on an individual's …

Sex matters: repetitive mild traumatic brain injury in adolescent rats

DK Wright, TJ O'Brien, SR Shultz… - Annals of clinical and …, 2017 - Wiley Online Library
Objective Whether sex differences contribute to the heterogeneity of mild traumatic brain
injury (mTBI) and repeated mTBI (Rm TBI) outcomes in adolescents is unknown. Therefore …

Peripheral blood and salivary biomarkers of blood–brain barrier permeability and neuronal damage: clinical and applied concepts

D Janigro, DM Bailey, S Lehmann, J Badaut… - Frontiers in …, 2021 - frontiersin.org
Within the neurovascular unit (NVU), the blood–brain barrier (BBB) operates as a key
cerebrovascular interface, dynamically insulating the brain parenchyma from peripheral …

Potential biomarkers in Experimental Animal models for traumatic brain Injury

UM Deshetty, P Periyasamy - Journal of clinical medicine, 2023 - mdpi.com
Traumatic brain injury (TBI) is a complex and multifaceted disorder that has become a
significant public health concern worldwide due to its contribution to mortality and morbidity …

[HTML][HTML] Behavioral, axonal, and proteomic alterations following repeated mild traumatic brain injury: novel insights using a clinically relevant rat model

L Pham, DK Wright, WT O'Brien, J Bain, C Huang… - Neurobiology of …, 2021 - Elsevier
A history of mild traumatic brain injury (mTBI) is linked to a number of chronic neurological
conditions, however there is still much unknown about the underlying mechanisms. To …

Treatment with an interleukin-1 receptor antagonist mitigates neuroinflammation and brain damage after polytrauma

M Sun, RD Brady, DK Wright, HA Kim, SR Zhang… - Brain, behavior, and …, 2017 - Elsevier
Traumatic brain injury (TBI) and long bone fracture are common in polytrauma. This injury
combination in mice results in elevated levels of the pro-inflammatory cytokine interleukin-1β …