The CNS critically relies on the formation and proper function of its vasculature during
development, adult homeostasis and disease. Angiogenesis—the formation of new blood …

Lymphatic vessels maintain tissue fluid homeostasis by returning to blood circulation
interstitial fluid that has extravasated from the blood capillaries. They provide a trafficking …

Vascular malformations are thought to be monogenic disorders that result in dysregulated
growth of blood vessels. In the brain, cerebral cavernous malformations (CCMs) arise owing …

Cerebral cavernous malformations are acquired vascular anomalies that constitute a
common cause of central nervous system hemorrhage and stroke. The past 2 decades have …

The vast blood-vessel network of the circulatory system is crucial for maintaining bodily
homeostasis, delivering essential molecules and blood cells, and removing waste products …

Abstract Background Cerebral cavernous malformations (CCMs) are common sporadic and
inherited vascular malformations of the central nervous system. Although familial CCMs are …

The YAP/TAZ transcriptional programme is not only a well-established driver of cancer
progression and metastasis but also an important stimulator of tissue regeneration. Here we …

The complexity of the blood–brain barrier (BBB) and neurovascular unit (NVU) was and still
is a challenge to bridge. A highly selective, restrictive and dynamic barrier, formed at the …

Cerebral cavernous malformation (CCM) is a rare neurovascular disease that is
characterized by enlarged and irregular blood vessels that often lead to cerebral …

Tight junction (TJ) proteins form a continuous intercellular network creating a barrier with
selective regulation of water, ion, and solutes across endothelial, epithelial, and glial tissues …