Past, present, and future of annexin A5: from protein discovery to clinical applications

HH Boersma, BLJH Kietselaer, LML Stolk… - Journal of nuclear …, 2005 - Soc Nuclear Med
In this article, we review the clinical aspects of imaging with the programmed cell–detecting
protein annexin A5 (anxA5). AnxA5 binds to phosphatidylserine, which is one of the “eat me” …

Positron emission tomography as an imaging biomarker

WA Weber - Journal of Clinical Oncology, 2006 - ascopubs.org
Positron emission tomography (PET) allows noninvasive, quantitative studies of various
biologic processes in the tumor tissue. By using PET, investigators can study the …

[HTML][HTML] Expression, purification and use of recombinant annexin V for the detection of apoptotic cells

SE Logue, M Elgendy, SJ Martin - Nature protocols, 2009 - nature.com
Apoptosis is a mode of programmed cell death that is widely used to eliminate cells during
development, tissue homeostasis, infection or in response to injury. Alterations to the plasma …

In vivo detection of apoptosis

FG Blankenberg - Journal of Nuclear Medicine, 2008 - Soc Nuclear Med
After several decades of debate, it is now widely acknowledged that apoptosis, also known
as programmed cell death, is central to homoeostasis and normal development and …

[HTML][HTML] Phosphatidylserine targeting for diagnosis and treatment of human diseases

K Schutters, C Reutelingsperger - Apoptosis, 2010 - Springer
Cells are able to execute apoptosis by activating series of specific biochemical reactions.
One of the most prominent characteristics of cell death is the externalization of …

Detecting retinal cell stress and apoptosis with DARC: Progression from lab to clinic

MF Cordeiro, D Hill, R Patel, P Corazza… - Progress in Retinal and …, 2022 - Elsevier
Abstract DARC (Detection of Apoptosing Retinal Cells) is a retinal imaging technology that
has been developed within the last 2 decades from basic laboratory science to Phase 2 …

Low-dose palliative radiotherapy for cutaneous B-and T-cell lymphomas

KJ Neelis, EC Schimmel, MH Vermeer, NJ Senff… - International Journal of …, 2009 - Elsevier
PURPOSE: To determine the efficacy of low-dose palliative radiotherapy for both low-grade
malignant cutaneous B-cell lymphomas (CBCLs) and cutaneous T-cell lymphomas (mycosis …

Optical and magnetic resonance imaging of cell death and platelet activation using annexin A5-functionalized quantum dots

L Prinzen, RJJHM Miserus, A Dirksen, TM Hackeng… - Nano …, 2007 - ACS Publications
A quantum-dot-based nanoparticle is presented, allowing visualization of cell death and
activated platelets with fluorescence imaging and MRI. The particle exhibits intense …

In vivo imaging of apoptosis by 99mTc-Annexin V scintigraphy: visual analysis in relation to treatment response

M Kartachova, RLM Haas, RAV Olmos… - Radiotherapy and …, 2004 - Elsevier
BACKGROUND AND PURPOSE: Anticancer therapy induces apoptosis in a dose-and time-
dependent fashion. 99mTc-Hynic-rh-Annexin V scintigraphy (TAVS) enables non-invasive in …

Clinical biomarkers and imaging for radiotherapy-induced cell death

M Verheij - Cancer and Metastasis Reviews, 2008 - Springer
Introduction Radiotherapy, like most anticancer treatments, achieves its therapeutic effect by
inducing different types of cell death in tumors. Cell death markers and imaging modalities …