Natural products have been a rich source of compounds for drug discovery. However, their
use has diminished in the past two decades, in part because of technical barriers to …

3-3 proteins are a family of structurally similar phospho-binding proteins that regulate
essentially every major cellular function. Decades of research on 14-3-3s have revealed a …

Direct interactions between proteins are essential for the regulation of their functions in
biological pathways. Targeting the complex network of protein–protein interactions (PPIs) …

Since Hedin's characterization of trypsin and antitrypsin in 1906,(1) arguably the first
account of a regulatory protein–protein interaction (PPI), contemporary understanding of …

Tissue repair is a very complex event and involves a continuously orchestrated sequence of
signals and responses from platelets, fibroblasts, epithelial, endothelial and immune cells …

Virtual screening has played a significant role in the discovery of small molecule inhibitors of
therapeutic targets in last two decades. Various ligand and structure-based virtual screening …

The systematic stabilization of protein–protein interactions (PPI) has great potential as
innovative drug discovery strategy to target novel and hard-to-drug protein classes. The …

A powerful early approach to evaluating the druggability of proteins involved determining the
hit rate in NMR-based screening of a library of small compounds. Here, we show that a …

14-3-3 is a class of proteins able to interact with a multitude of targets by establishing protein-
protein interactions (PPIs). They are usually found in all eukaryotes with a conserved …

There is growing interest within the pharmaceutical community to undertake biological
targets that involve protein− protein 1 and, in general, biomacromolecular interactions 2 (PPI …