Digital twins and automation of care in the intensive care unit

J Geoffrey Chase, C Zhou, JL Knopp… - Cyber–Physical …, 2023 - Wiley Online Library
Healthcare is under increasing demand pressure as societies age and expectations rise,
multiplied by increasing incidence of chronic diseases and decreasing available funding …

Robots and Intelligent Medical Devices in the Intensive Care Unit: Vision, State of the Art, and Economic Analysis

G Kosa, O Morozov, A Lehmann… - … on Medical Robotics …, 2023 - ieeexplore.ieee.org
Robotics is widely seen as a key enabling technology for the society of tomorrow. We
examine the role of robotics and intelligent medical devices in Intensive Care Medicine …

Virtual patients for mechanical ventilation in the intensive care unit

C Zhou, JG Chase, J Knopp, Q Sun, M Tawhai… - Computer Methods and …, 2021 - Elsevier
Background Mechanical ventilation (MV) is a core intensive care unit (ICU) therapy.
Significant inter-and intra-patient variability in lung mechanics and condition makes …

Quantifying ventilator unloading in CPAP ventilation

EFS Guy, JG Chase, JL Knopp, GM Shaw - Computers in Biology and …, 2022 - Elsevier
Background The intrinsic (muscular) patient effort driving inspiration in non-invasive
ventilation modes, such as continuous positive airway pressure (CPAP) therapy, has not …

[HTML][HTML] Airflow and dynamic circumference of abdomen and thorax for adults at varied continuous positive airway pressure ventilation settings and breath rates

EFS Guy, JL Knopp, T Lerios, JG Chase - Scientific Data, 2023 - nature.com
Continuous positive airway pressure (CPAP) ventilation is a commonly prescribed
respiratory therapy providing positive end-expiratory pressure (PEEP) to assist breathing …

Over-distension prediction via hysteresis loop analysis and patient-specific basis functions in a virtual patient model

Q Sun, JG Chase, C Zhou, MH Tawhai… - Computers in Biology …, 2022 - Elsevier
Background and objective Recruitment maneuvers (RMs) with subsequent positive-end-
expiratory-pressure (PEEP) have proven effective in recruiting lung volume and preventing …

Model-based estimation of negative inspiratory driving pressure in patients receiving invasive NAVA mechanical ventilation

JL Knopp, JG Chase, KT Kim, GM Shaw - Computer Methods and Programs …, 2021 - Elsevier
Background Optimisation of mechanical ventilation (MV) and weaning requires insight into
underlying patient breathing effort. Current identifiable models effectively describe lung …

Network data acquisition and monitoring system for intensive care mechanical ventilation treatment

QA Ng, YS Chiew, X Wang, CP Tan, MBM Nor… - Ieee …, 2021 - ieeexplore.ieee.org
The rise of model-based and machine learning methods have created increasingly realistic
opportunities to implement personalized, patient-specific mechanical ventilation (MV) in the …

[HTML][HTML] Respiratory pressure and split flow data collection device with rapid occlusion attachment

EFS Guy, JA Clifton, JL Knopp, LR Holder-Pearson… - HardwareX, 2023 - Elsevier
Respiratory model-based methods require datasets containing enough dynamics to ensure
model identifiability for development and validation. Rapid expiratory occlusion has been …

Digital twins in critical care: what, when, how, where, why?

JG Chase, C Zhou, JL Knopp, GM Shaw, K Näswall… - IFAC-PapersOnLine, 2021 - Elsevier
Healthcare and intensive care unit (ICU) medicine in particular, are facing a devastating
tsunami of rising demand multiplied by increasing chronic disease and aging demographics …