Ayahuasca's therapeutic potential: What we know–and what not

LO Maia, D Daldegan-Bueno, I Wießner… - European …, 2023 - Elsevier
The therapeutic potential of the psychedelic brew ayahuasca has been investigated in
preclinical and clinical studies. Currently, the most consistent evidence refers to depression …

A Systematic Review on the Therapeutic Effects of Ayahuasca

J Gonçalves, Â Luís, E Gallardo, AP Duarte - Plants, 2023 - mdpi.com
Traditional therapies, resorting to the use of plants, have acquired a great demand over the
years, both for economic reasons and the preference for natural treatments. Some studies …

Ayahuasca prevents oxidative stress in a rat model of depression elicited by unpredictable chronic mild stress

J Xavier, CP Farias, MSP Soares… - Archives of Clinical …, 2021 - SciELO Brasil
Background: Depression is a highly disabling common mental disorder and, due to its
multifactorial nature, the development of effective therapies is challenging and of great …

The current state of ayahuasca research in animal models: A systematic review

D Daldegan-Bueno, NM Simionato, VM Favaro… - Progress in Neuro …, 2023 - Elsevier
Rationale The psychedelic brew ayahuasca is increasingly being investigated for its
therapeutic potential. Animal models are essential to investigate the pharmacological effects …

Banisteriopsis caapi extract: Implications for neuroinflammatory pathways in Locus coeruleus lesion rodent model

SC Graça, IB Bustelli, ÉV Dos Santos… - Journal of …, 2025 - Elsevier
Ethnopharmacology relevance Ayahuasca is a beverage obtained from the decoctions of
Banisteriopsis caapi (Spruce ex Griseb.) Morton and Psychotria viridis Ruiz & Pav., used …

Wistar-Kyoto rats and chronically stressed Wistar rats present similar depression-and anxiety-like behaviors but different corticosterone and endocannabinoid system …

Z Wang, R van Bruggen, T Sandini, EV Hagen… - Progress in Neuro …, 2023 - Elsevier
The interplay of social, psychological, and biological stresses can trigger mental health
conditions such as major depressive disorder (MDD), adjustment disorder, and …

Psychedelics: A review of their effects on recalled aversive memories and fear/anxiety expression in rodents

I Werle, LJ Bertoglio - Neuroscience & Biobehavioral Reviews, 2024 - Elsevier
Threatening events and stressful experiences can lead to maladaptive memories and
related behaviors. Existing treatments often fail to address these issues linked to …

Ayahuasca: a review of historical, pharmacological, and therapeutic aspects

SGD Ruffell, M Crosland‐Wood… - Psychiatry and …, 2023 - Wiley Online Library
Ayahuasca is a psychedelic plant brew originating from the Amazon rainforest. It is formed
from two basic components, the Banisteriopsis caapi vine and a plant containing the potent …

Ayahuasca Pretreatment Prevents Sepsis-Induced Anxiety-Like Behavior, Neuroinflammation, and Oxidative Stress, and Increases Brain-Derived Neurotrophic Factor

RW de Camargo, L Joaquim, RS Machado… - Molecular …, 2024 - Springer
The psychoactive decoction Ayahuasca (AYA) used for therapeutic and religious purposes
by indigenous groups and peoples from Amazonian regions produces anti-inflammatory and …

New psychoactive substances—synthetic stimulants

MR Varì, S Pichini, R Giorgetti… - Wiley Interdisciplinary …, 2019 - Wiley Online Library
The expression “New Synthetic Stimulants” include classes of psychoactive compounds that
share subjective effects in humans such as boosted mood or euphoria, feelings of empathy …