T-type Ca2+ channels were originally called low-voltage-activated (LVA) channels because
they can be activated by small depolarizations of the plasma membrane. In many neurons …

The calcium ion (Ca2+) is the simplest and most versatile intracellular messenger known.
The discovery of Ca2+ sparks and a related family of elementary Ca2+ signaling events has …

▪ Abstract Recent advances—both experimental and theoretical—provide a tentative image
of the structures in Ca channels that make them exceptionally selective. The image is very …

The tight junction of epithelial cells excludes macromolecules but allows permeation of ions.
However, it is not clear whether this ion-conducting property is mediated by aqueous pores …

L-type Ca2+ channels are mediators of Ca2+ influx and the regulatory events accompanying
it and are pivotal in the function and dysfunction of ventricular cardiac myocytes. L-type …

Intracellular Ca2+ regulates numerous proteins and cellular functions and can vary
substantially over submicron and submillisecond scales, so precisely localized fast detection …

Store‐operated Ca2+ entry through Orai1 channels is a primary mechanism for Ca2+ entry
in many cells and mediates numerous cellular effector functions ranging from gene …

Detection of image motion direction begins in the retina, with starburst amacrine cells
(SACs) playing a major role. SACs generate larger dendritic Ca2+ signals when motion is …

CaV1. 3 channels regulate excitability in many neurons. As is the case for all voltage-gated
channels, it is widely assumed that individual CaV1. 3 channels behave independently with …

The use of Ca 2+ for intracellular signalling necessitates tight local and global control of
cytoplasmic Ca 2+ concentration, and mechanisms for maintaining the net Ca 2+ balance. It …