[HTML][HTML] Oxidative stress, free radicals and antioxidants: Potential crosstalk in the pathophysiology of human diseases
P Chaudhary, P Janmeda, AO Docea… - Frontiers in …, 2023 - frontiersin.org
Introduction: Free radicals are reactive oxygen species that constantly circulate through the
body and occur as a side effect of many reactions that take place in the human body. Under …
body and occur as a side effect of many reactions that take place in the human body. Under …
[HTML][HTML] Targeting PI3K/Akt signal transduction for cancer therapy
Y He, MM Sun, GG Zhang, J Yang, KS Chen… - Signal transduction and …, 2021 - nature.com
Abstract The phosphatidylinositol 3-kinase (PI3K)/Akt pathway plays a crucial role in various
cellular processes and is aberrantly activated in cancers, contributing to the occurrence and …
cellular processes and is aberrantly activated in cancers, contributing to the occurrence and …
[HTML][HTML] The design of small-molecule prodrugs and activatable phototherapeutics for cancer therapy
Cancer remains as one of the most significant health problems, with approximately 19
million people diagnosed worldwide each year. Chemotherapy is a routinely used method to …
million people diagnosed worldwide each year. Chemotherapy is a routinely used method to …
[HTML][HTML] Recent progress in the development of fluorescent probes for imaging pathological oxidative stress
Y Geng, Z Wang, J Zhou, M Zhu, J Liu… - Chemical Society …, 2023 - pubs.rsc.org
Oxidative stress is closely related to the physiopathology of numerous diseases. Reactive
oxygen species (ROS), reactive nitrogen species (RNS), and reactive sulfur species (RSS) …
oxygen species (ROS), reactive nitrogen species (RNS), and reactive sulfur species (RSS) …
Biosystem‐inspired engineering of nanozymes for biomedical applications
L Zhang, H Wang, X Qu - Advanced Materials, 2024 - Wiley Online Library
Nanozymes with intrinsic enzyme‐mimicking activities have shown great potential to
become surrogates of natural enzymes in many fields by virtue of their advantages of high …
become surrogates of natural enzymes in many fields by virtue of their advantages of high …
[HTML][HTML] Nrf2 and oxidative stress: A general overview of mechanisms and implications in human disease
V Ngo, ML Duennwald - Antioxidants, 2022 - mdpi.com
Organisms are continually exposed to exogenous and endogenous sources of reactive
oxygen species (ROS) and other oxidants that have both beneficial and deleterious effects …
oxygen species (ROS) and other oxidants that have both beneficial and deleterious effects …
Inflammaging and osteoarthritis
Osteoarthritis is a highly prevalent disease particularly in subjects over 65 years of age
worldwide. While in the past it was considered a mere consequence of cartilage degradation …
worldwide. While in the past it was considered a mere consequence of cartilage degradation …
[HTML][HTML] Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases
Y Yu, Y Yan, F Niu, Y Wang, X Chen, G Su, Y Liu… - Cell death …, 2021 - nature.com
Ferroptosis, a recently identified and iron-dependent cell death, differs from other cell death
such as apoptosis, necroptosis, pyroptosis, and autophagy-dependent cell death. This form …
such as apoptosis, necroptosis, pyroptosis, and autophagy-dependent cell death. This form …
[HTML][HTML] Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors
S Xu, O Chaudhary, P Rodríguez-Morales, X Sun… - Immunity, 2021 - cell.com
A common metabolic alteration in the tumor microenvironment (TME) is lipid accumulation, a
feature associated with immune dysfunction. Here, we examined how CD8+ tumor infiltrating …
feature associated with immune dysfunction. Here, we examined how CD8+ tumor infiltrating …
Ultraprocessed food and chronic noncommunicable diseases: a systematic review and meta‐analysis of 43 observational studies
This systematic review and meta‐analysis investigated the association between
consumption of ultraprocessed food and noncommunicable disease risk, morbidity and …
consumption of ultraprocessed food and noncommunicable disease risk, morbidity and …