Host genetics and infectious disease: new tools, insights and translational opportunities
Understanding how human genetics influence infectious disease susceptibility offers the
opportunity for new insights into pathogenesis, potential drug targets, risk stratification …
opportunity for new insights into pathogenesis, potential drug targets, risk stratification …
Main components of fish immunity: An overview of the fish immune system
DM Mokhtar, G Zaccone, A Alesci, M Kuciel… - Fishes, 2023 - mdpi.com
Cellular immune responses consist of innate and adaptive cell-mediated immune
mechanisms, where all leukocyte subpopulations are included. Among these are vital …
mechanisms, where all leukocyte subpopulations are included. Among these are vital …
Host–parasite co-evolution and its genomic signature
Studies in diverse biological systems have indicated that host–parasite co-evolution is
responsible for the extraordinary genetic diversity seen in some genomic regions, such as …
responsible for the extraordinary genetic diversity seen in some genomic regions, such as …
[HTML][HTML] Individual HLA heterogeneity and its implications for cellular immune evasion in cancer and beyond
S Pagliuca, C Gurnari, MT Rubio, V Visconte… - Frontiers in …, 2022 - frontiersin.org
Structural and functional variability of human leukocyte antigen (HLA) is the foundation for
competent adaptive immune responses against pathogen and tumor antigens as it assures …
competent adaptive immune responses against pathogen and tumor antigens as it assures …
Selection balancing at innate immune genes: Adaptive polymorphism maintenance in toll-like receptors
Balancing selection is a classic mechanism for maintaining variability in immune genes
involved in host–pathogen interactions. However, it remains unclear how widespread the …
involved in host–pathogen interactions. However, it remains unclear how widespread the …
[HTML][HTML] The biogenesis of the immunopeptidome
A Admon - Seminars in Immunology, 2023 - Elsevier
The immunopeptidome is the repertoire of peptides bound and presented by the MHC class
I, class II, and non-classical molecules. The peptides are produced by the degradation of …
I, class II, and non-classical molecules. The peptides are produced by the degradation of …
Inferring balancing selection from genome-scale data
The identification of genomic regions and genes that have evolved under natural selection is
a fundamental objective in the field of evolutionary genetics. While various approaches have …
a fundamental objective in the field of evolutionary genetics. While various approaches have …
How HLA diversity is apportioned: influence of selection and relevance to transplantation
In his 1972 paper 'The apportionment of human diversity', Lewontin showed that, when
averaged over loci, genetic diversity is predominantly attributable to differences among …
averaged over loci, genetic diversity is predominantly attributable to differences among …
Interaction between MHC diversity and constitution, gut microbiota and Astrovirus infections in a neotropical bat
R Fleischer, DW Schmid, Wasimuddin… - Molecular …, 2022 - Wiley Online Library
Astroviruses (AstVs) infect numerous mammalian species including reservoirs such as bats.
Peptides encoded by the genes of the highly polymorphic Major Histocompatibility Complex …
Peptides encoded by the genes of the highly polymorphic Major Histocompatibility Complex …
Tutorial: a statistical genetics guide to identifying HLA alleles driving complex disease
The human leukocyte antigen (HLA) locus is associated with more complex diseases than
any other locus in the human genome. In many diseases, HLA explains more heritability …
any other locus in the human genome. In many diseases, HLA explains more heritability …