The NOTCH gene was identified approximately 110 years ago. Classical studies have
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …

Triple negative breast cancer (TNBC) is most aggressive subtype of breast cancers with high
probability of metastasis as well as lack of specific targets and targeted therapeutics. TNBC …

The tumor microenvironment (TME) plays key roles in promoting disease progression in the
aggressive triple-negative subtype of breast cancer (TNBC; Basal/Basal-like). Here, we took …

The Notch signaling pathway is an architecturally simple signaling mechanism, well known
for its role in cell fate regulation during organ development and in tissue homeostasis. In …

The anti-tumor activities of some members of the chemokine family are often overcome by
the functions of many chemokines that are strongly and causatively linked with increased …

In humans, Interleukin-8 (IL-8 or CXCL8) is a granulocytic chemokine with multiple roles
within the tumor microenvironment (TME), such as recruiting immunosuppressive cells to the …

Abstract Triple Negative Breast Cancer (TNBC) is the most lethal subtype of breast cancer.
Despite the successes of emerging targeted therapies, relapse, recurrence, and therapy …

Mesenchymal stem/stromal cells (MSCs) encompass a heterogeneous population of
fibroblastic progenitor cells that reside in multiple tissues around the body. They are …

Tumor immunotherapy has achieved remarkable efficacy, with immune‐checkpoint
inhibitors as especially promising candidates for cancer therapy. However, some issues …

Cellular heterogeneity poses an immense therapeutic challenge in cancer due to a constant
change in tumor cell characteristics, endowing cancer cells with the ability to dynamically …