Histone post-translational modifications—cause and consequence of genome function
G Millán-Zambrano, A Burton, AJ Bannister… - Nature Reviews …, 2022 - nature.com
Much has been learned since the early 1960s about histone post-translational modifications
(PTMs) and how they affect DNA-templated processes at the molecular level. This …
(PTMs) and how they affect DNA-templated processes at the molecular level. This …
The molecular basis of heterochromatin assembly and epigenetic inheritance
SIS Grewal - Molecular cell, 2023 - cell.com
Heterochromatin plays a fundamental role in gene regulation, genome integrity, and
silencing of repetitive DNA elements. Histone modifications are essential for the …
silencing of repetitive DNA elements. Histone modifications are essential for the …
[HTML][HTML] Diverse silent chromatin states modulate genome compartmentalization and loop extrusion barriers
The relationships between chromosomal compartmentalization, chromatin state and function
are poorly understood. Here by profiling long-range contact frequencies in HCT116 colon …
are poorly understood. Here by profiling long-range contact frequencies in HCT116 colon …
Genome control by SMC complexes
C Hoencamp, BD Rowland - Nature Reviews Molecular Cell Biology, 2023 - nature.com
Many cellular processes require large-scale rearrangements of chromatin structure.
Structural maintenance of chromosomes (SMC) protein complexes are molecular machines …
Structural maintenance of chromosomes (SMC) protein complexes are molecular machines …
HP1 reshapes nucleosome core to promote phase separation of heterochromatin
Heterochromatin affects genome function at many levels. It enables heritable gene
repression, maintains chromosome integrity and provides mechanical rigidity to the …
repression, maintains chromosome integrity and provides mechanical rigidity to the …
[HTML][HTML] HP1 proteins compact DNA into mechanically and positionally stable phase separated domains
In mammals, HP1-mediated heterochromatin forms positionally and mechanically stable
genomic domains even though the component HP1 paralogs, HP1α, HP1β, and HP1γ …
genomic domains even though the component HP1 paralogs, HP1α, HP1β, and HP1γ …
H3K9me3-dependent heterochromatin: barrier to cell fate changes
Establishing and maintaining cell identity depends on the proper regulation of gene
expression, as specified by transcription factors and reinforced by epigenetic mechanisms …
expression, as specified by transcription factors and reinforced by epigenetic mechanisms …
Regulation of nucleosome dynamics by histone modifications
GE Zentner, S Henikoff - Nature structural & molecular biology, 2013 - nature.com
Chromatin is a dynamic structure that must respond to myriad stimuli to regulate access to
DNA, and chemical modification of histones is a major means by which the cell modulates …
DNA, and chemical modification of histones is a major means by which the cell modulates …
Perceiving the epigenetic landscape through histone readers
CA Musselman, ME Lalonde, J Côté… - Nature structural & …, 2012 - nature.com
Post-translational modifications (PTMs) of histones provide a fine-tuned mechanism for
regulating chromatin structure and dynamics. PTMs can alter direct interactions between …
regulating chromatin structure and dynamics. PTMs can alter direct interactions between …
New insights into nucleosome and chromatin structure: an ordered state or a disordered affair?
K Luger, ML Dechassa, DJ Tremethick - Nature reviews Molecular cell …, 2012 - nature.com
The compaction of genomic DNA into chromatin has profound implications for the regulation
of key processes such as transcription, replication and DNA repair. Nucleosomes, the …
of key processes such as transcription, replication and DNA repair. Nucleosomes, the …