Root of the tree: the significance, evolution, and origins of the ribosome
The ribosome is an ancient molecular fossil that provides a telescope to the origins of life.
Made from RNA and protein, the ribosome translates mRNA to coded protein in all living …
Made from RNA and protein, the ribosome translates mRNA to coded protein in all living …
Peptides before and during the nucleotide world: An origins story emphasizing cooperation between proteins and nucleic acids
SD Fried, K Fujishima, M Makarov… - Journal of the …, 2022 - royalsocietypublishing.org
Recent developments in Origins of Life research have focused on substantiating the
narrative of an abiotic emergence of nucleic acids from organic molecules of low molecular …
narrative of an abiotic emergence of nucleic acids from organic molecules of low molecular …
[HTML][HTML] Interchangeable utilization of metals: New perspectives on the impacts of metal ions employed in ancient and extant biomolecules
DGJ Smethurst, N Shcherbik - Journal of Biological Chemistry, 2021 - ASBMB
Metal ions provide considerable functionality across biological systems, and their utilization
within biomolecules has adapted through changes in the chemical environment to maintain …
within biomolecules has adapted through changes in the chemical environment to maintain …
The peptidyl transferase center: a window to the past
MR Tirumalai, M Rivas, Q Tran… - … and Molecular Biology …, 2021 - Am Soc Microbiol
SUMMARY In his 2001 article,“Translation: in retrospect and prospect,” the late Carl Woese
made a prescient observation that there was a need for the then-current view of translation …
made a prescient observation that there was a need for the then-current view of translation …
One-Pot De Novo Synthesis of [4Fe-4S] Proteins Using a Recombinant SUF System under Aerobic Conditions
Fe–S clusters are essential cofactors mediating electron transfer in respiratory and
metabolic networks. However, obtaining active [4Fe-4S] proteins with heterologous …
metabolic networks. However, obtaining active [4Fe-4S] proteins with heterologous …
Selective metal chelation by a thiosemicarbazone derivative interferes with mitochondrial respiration and ribosome biogenesis in Candida albicans
X Duan, Z Xie, L Ma, X Jin, M Zhang, Y Xu… - Microbiology …, 2022 - Am Soc Microbiol
Metal chelation is generally considered as a promising antifungal approach but its specific
mechanisms are unclear. Here, we identify 13 thiosemicarbazone derivatives that exert …
mechanisms are unclear. Here, we identify 13 thiosemicarbazone derivatives that exert …
The czcD (NiCo) Riboswitch Responds to Iron(II)
J Xu, JA Cotruvo Jr - Biochemistry, 2020 - ACS Publications
Iron is essential for nearly every organism, and mismanagement of its intracellular
concentrations (either deficiency or excess) contributes to diminished virulence in human …
concentrations (either deficiency or excess) contributes to diminished virulence in human …
The regulatory role of Fur-encoding SCLAV_3199 in iron homeostasis in Streptomyces clavuligerus
Iron homeostasis is strictly regulated by complex cascades connected with secondary
metabolism in bacteria. Ferric uptake regulators ('Fur's), siderophores, efflux systems, and …
metabolism in bacteria. Ferric uptake regulators ('Fur's), siderophores, efflux systems, and …
[HTML][HTML] Iron-mediated degradation of ribosomes under oxidative stress is attenuated by manganese
DGJ Smethurst, N Kovalev, ER McKenzie… - Journal of Biological …, 2020 - ASBMB
Protein biosynthesis is fundamental to cellular life and requires the efficient functioning of
the translational machinery. At the center of this machinery is the ribosome, a …
the translational machinery. At the center of this machinery is the ribosome, a …
Goldilocks and RNA: where Mg2+ concentration is just right
R Guth-Metzler, AM Mohamed, ET Cowan… - Nucleic Acids …, 2023 - academic.oup.com
Magnesium, the most abundant divalent cation in cells, catalyzes RNA cleavage but also
promotes RNA folding. Because folding can protect RNA from cleavage, we predicted a …
promotes RNA folding. Because folding can protect RNA from cleavage, we predicted a …