The ribosome is an ancient molecular fossil that provides a telescope to the origins of life.
Made from RNA and protein, the ribosome translates mRNA to coded protein in all living …

Recent developments in Origins of Life research have focused on substantiating the
narrative of an abiotic emergence of nucleic acids from organic molecules of low molecular …

Metal ions provide considerable functionality across biological systems, and their utilization
within biomolecules has adapted through changes in the chemical environment to maintain …

SUMMARY In his 2001 article,“Translation: in retrospect and prospect,” the late Carl Woese
made a prescient observation that there was a need for the then-current view of translation …

Fe–S clusters are essential cofactors mediating electron transfer in respiratory and
metabolic networks. However, obtaining active [4Fe-4S] proteins with heterologous …

Metal chelation is generally considered as a promising antifungal approach but its specific
mechanisms are unclear. Here, we identify 13 thiosemicarbazone derivatives that exert …

Iron is essential for nearly every organism, and mismanagement of its intracellular
concentrations (either deficiency or excess) contributes to diminished virulence in human …

Iron homeostasis is strictly regulated by complex cascades connected with secondary
metabolism in bacteria. Ferric uptake regulators ('Fur's), siderophores, efflux systems, and …

Protein biosynthesis is fundamental to cellular life and requires the efficient functioning of
the translational machinery. At the center of this machinery is the ribosome, a …

Magnesium, the most abundant divalent cation in cells, catalyzes RNA cleavage but also
promotes RNA folding. Because folding can protect RNA from cleavage, we predicted a …