Rho family guanosine triphosphatases (GTPases) regulate cellular signaling and
cytoskeletal dynamics, playing a pivotal role in cell adhesion, migration, and cell cycle …

Rho GTPases oscillate between an inactive GDP-bound state and an active GTP-bound
state. They are activated by Rho Guanine nucleotide Exchange Factors (GEF), which …

Experience-dependent plasticity shapes postnatal development of neural circuits, but the
mechanisms that refine dendritic arbors, remodel spines, and impair synaptic activity are …

INTRODUCTION Eusocial insects, such as ants, live a communal lifestyle within colonies of
close genetic relatives. Colony members are organized into castes defined by behavioral …

The Rho-guanine nucleotide exchange factor (RhoGEF) TRIO acts as a key regulator of
neuronal migration, axonal outgrowth, axon guidance, and synaptogenesis by activating the …

Recently, we marked TRIO for the first time as a candidate gene for intellectual disability (ID).
Across diverse vertebrate species, TRIO is a well-conserved Rho GTPase regulator that is …

Dendrite morphology is necessary for the correct integration of inputs that neurons receive.
The branching mechanisms allowing neurons to acquire their type-specific morphology …

Proper morphogenesis of dendrites plays a fundamental role in the establishment of neural
circuits. The molecular mechanism by which dendrites grow highly complex branches is not …

Background Neurons are one of the most structurally and functionally diverse cell types
found in nature, owing in large part to their unique class specific dendritic architectures …

Bipolar disorder, schizophrenia, autism and intellectual disability are complex
neurodevelopmental disorders, debilitating millions of people. Therapeutic progress is …