Primary immunodeficiency and autoimmunity: a comprehensive review

L Amaya-Uribe, M Rojas, G Azizi, JM Anaya… - Journal of …, 2019 - Elsevier
The primary immunodeficiency diseases (PIDs) include many genetic disorders that affect
different components of the innate and adaptive responses. The number of distinct genetic …

[HTML][HTML] Extracellular vesicles and their cells of origin: Open issues in autoimmune diseases

A Haghighitalab, M Dominici, MM Matin… - Frontiers in …, 2023 - frontiersin.org
The conventional therapeutic approaches to treat autoimmune diseases through
suppressing the immune system, such as steroidal and non-steroidal anti-inflammatory …

Genetic, immunological, and clinical features of the first Mexican cohort of patients with chronic granulomatous disease

L Blancas-Galicia, E Santos-Chávez… - Journal of clinical …, 2020 - Springer
Purpose Chronic granulomatous disease (CGD) is a primary immunodeficiency
characterized by an inability of phagocytes to produce reactive oxygen species, impairing …

Genotype, oxidase status, and preceding infection or autoinflammation do not affect allogeneic HCT outcomes for CGD

JW Leiding, DE Arnold, S Parikh, B Logan, RA Marsh… - Blood, 2023 - ashpublications.org
Chronic granulomatous disease (CGD) is a primary immunodeficiency characterized by life-
threatening infections and inflammatory conditions. Hematopoietic cell transplantation (HCT) …

[HTML][HTML] Autoimmunity following allogeneic hematopoietic stem cell transplantation

NP Buxbaum, SZ Pavletic - Frontiers in Immunology, 2020 - frontiersin.org
Autoimmune manifestations after allogeneic hematopoietic stem cell transplantation
(AHSCT) are rare and poorly understood due to the complex interplay between the …

[HTML][HTML] Cellular therapies in chronic granulomatous disease

T Güngör, R Chiesa - Frontiers in pediatrics, 2020 - frontiersin.org
Allogeneic hematopoietic stem cell transplantation (HSCT) has become the main curative
treatment in patients with chronic granulomatous disease (CGD). CGD is caused by …

Immune-mediated cytopenias after hematopoietic cell transplantation: pathophysiology, clinical manifestations, diagnosis, and treatment strategies

TF Michniacki, CL Ebens, SW Choi - Current oncology reports, 2019 - Springer
Abstract Purpose of Review Discuss the pathophysiology, clinical presentation, diagnosis,
and treatment of immune-mediated cytopenias (IMC) after hematopoietic cell transplantation …

Two decades of excellent transplant survival for chronic granulomatous disease: a supraregional immunology transplant center report

SH Lum, T Flood, S Hambleton… - Blood, The Journal …, 2019 - ashpublications.org
Chronic granulomatous disease (CGD), an inherited immunodeficiency resulting from
defects in the reduced NAD phosphate oxidase complex rendering phagocytes deficient in …

Autoimmune hemolytic anemia and immune thrombocytopenia following hematopoietic stem cell transplant: a critical review of the literature

CE Neunert, JM Despotovic - Pediatric Blood & Cancer, 2019 - Wiley Online Library
Autoimmune cytopenias (AIC) post‐hematopoietic stem cell transplant (HSCT) are rare but
exceptionally challenging complication. We conducted a comprehensive literature review …

[HTML][HTML] Lentiviral gene therapy rescues p47phox chronic granulomatous disease and the ability to fight Salmonella infection in mice

A Schejtman, WC Aragão-Filho, S Clare, M Zinicola… - Gene therapy, 2020 - nature.com
Chronic granulomatous disease (CGD) is an inherited primary immunodeficiency disorder
characterised by recurrent and often life-threatening infections and hyperinflammation. It is …