Structure, properties of gossypol and its derivatives—from physiological activities to drug discovery and drug design
Y Liu, L Wang, L Zhao, Y Zhang - Natural product reports, 2022 - pubs.rsc.org
Covering up to 2022 Gossypol is a polyphenolic compound isolated from cottonseed. There
are two optical enantiomers of gossypol,(−)-gossypol and (+)-gossypol. Gossypol exists as …
are two optical enantiomers of gossypol,(−)-gossypol and (+)-gossypol. Gossypol exists as …
The role of the PI3K/AKT/mTOR signalling pathway in male reproduction
CY Deng, M Lv, BH Luo, SZ Zhao… - Current molecular …, 2021 - ingentaconnect.com
Male fertility is closely related to the normal function of the hypothalamicpituitary-testicular
axis. The testis is an important male reproductive organ that secretes androgen and …
axis. The testis is an important male reproductive organ that secretes androgen and …
The nutritional and industrial significance of cottonseeds and genetic techniques in gossypol detoxification
V Ninkuu, Z Liu, Y Zhou, X Sun - Plants, People, Planet, 2024 - Wiley Online Library
Societal Impact Statement Gossypol and its derivatives represent a class of toxic and
immunosuppressive compounds that are naturally synthesized in cottonseed. These …
immunosuppressive compounds that are naturally synthesized in cottonseed. These …
Chlorpyrifos inhibits sperm maturation and induces a decrease in mouse male fertility
Background Pesticides, especially organophosphorus pesticides such as chlorpyrifos (CPF),
play an important role in modern agriculture. Studies have shown that pesticide residues are …
play an important role in modern agriculture. Studies have shown that pesticide residues are …
Biodegradation of Free Gossypol by Helicoverpa armigera Carboxylesterase Expressed in Pichia pastoris
L Zhang, X Yang, R Huang, C Nie, J Niu, C Chen… - Toxins, 2022 - mdpi.com
Gossypol is a polyphenolic toxic secondary metabolite derived from cotton. Free gossypol in
cotton meal is remarkably harmful to animals. Furthermore, microbial degradation of …
cotton meal is remarkably harmful to animals. Furthermore, microbial degradation of …
Effects of a high‐fat diet on rat epididymis
S Falvo, D Latino, A Santillo… - … Zoology Part A …, 2023 - Wiley Online Library
The epididymis plays an essential role in reproduction, promoting sperm cell maturation. In
this study, we investigated the effects of a high‐fat diet (HFD) in the three regions of the …
this study, we investigated the effects of a high‐fat diet (HFD) in the three regions of the …
Microcystin-LR inhibits testosterone synthesis via reactive oxygen species-mediated GCN2/eIF2α pathway in mouse testes
L Gao, J Chen, J Li, AQ Cui, WW Zhang, XL Li… - Science of The Total …, 2021 - Elsevier
Previous studies demonstrated that microcystin-leucine-arginine (MC-LR) disrupted
testosterone (T) synthesis, but the underlying mechanisms are not entirely elucidated. This …
testosterone (T) synthesis, but the underlying mechanisms are not entirely elucidated. This …
A novel Zn-MOF fluorescent probe for highly sensitive and rapid detection of gossypol in cottonseed oil and fetal bovine serum
W Li, J Zhu, X Qi, C Sun, W Li, Z Chang - Food Bioscience, 2024 - Elsevier
Gossypol is a poisonous substance in cottonseed which seriously harms the internal organs,
blood vessels, nerves, and reproductive systems of organisms. Therefore, detecting …
blood vessels, nerves, and reproductive systems of organisms. Therefore, detecting …
Risk compounds, potential mechanisms and biomarkers of traditional Chinese medicine‐induced reproductive toxicity
Q Li, X Yan, Y Zhang, J Zhou, L Yang… - Journal of Applied …, 2022 - Wiley Online Library
With the increasing application of traditional Chinese medicine (TCM), TCM‐induced
reproductive toxicity has gradually aroused people's concern. Various TCM, such as …
reproductive toxicity has gradually aroused people's concern. Various TCM, such as …
Gene expression pattern of Peyer's patch lymphocytes exposed to kagocel suggests pattern-recognition receptors mediate its action
AA Andreev-Andrievskiy, RA Zinovkin… - Frontiers in …, 2021 - frontiersin.org
Kagocel is a synthetic carboxymethylcellulose derivative copolymerized with gossypol.
Clinical data evidence its safety and efficiency for the treatment of flu and other viral …
Clinical data evidence its safety and efficiency for the treatment of flu and other viral …