Structure, properties of gossypol and its derivatives—from physiological activities to drug discovery and drug design

Y Liu, L Wang, L Zhao, Y Zhang - Natural product reports, 2022 - pubs.rsc.org
Covering up to 2022 Gossypol is a polyphenolic compound isolated from cottonseed. There
are two optical enantiomers of gossypol,(−)-gossypol and (+)-gossypol. Gossypol exists as …

The role of the PI3K/AKT/mTOR signalling pathway in male reproduction

CY Deng, M Lv, BH Luo, SZ Zhao… - Current molecular …, 2021 - ingentaconnect.com
Male fertility is closely related to the normal function of the hypothalamicpituitary-testicular
axis. The testis is an important male reproductive organ that secretes androgen and …

The nutritional and industrial significance of cottonseeds and genetic techniques in gossypol detoxification

V Ninkuu, Z Liu, Y Zhou, X Sun - Plants, People, Planet, 2024 - Wiley Online Library
Societal Impact Statement Gossypol and its derivatives represent a class of toxic and
immunosuppressive compounds that are naturally synthesized in cottonseed. These …

Chlorpyrifos inhibits sperm maturation and induces a decrease in mouse male fertility

X Zhang, W Cui, KE Wang, R Chen, M Chen… - Environmental …, 2020 - Elsevier
Background Pesticides, especially organophosphorus pesticides such as chlorpyrifos (CPF),
play an important role in modern agriculture. Studies have shown that pesticide residues are …

Biodegradation of Free Gossypol by Helicoverpa armigera Carboxylesterase Expressed in Pichia pastoris

L Zhang, X Yang, R Huang, C Nie, J Niu, C Chen… - Toxins, 2022 - mdpi.com
Gossypol is a polyphenolic toxic secondary metabolite derived from cotton. Free gossypol in
cotton meal is remarkably harmful to animals. Furthermore, microbial degradation of …

Effects of a high‐fat diet on rat epididymis

S Falvo, D Latino, A Santillo… - … Zoology Part A …, 2023 - Wiley Online Library
The epididymis plays an essential role in reproduction, promoting sperm cell maturation. In
this study, we investigated the effects of a high‐fat diet (HFD) in the three regions of the …

Microcystin-LR inhibits testosterone synthesis via reactive oxygen species-mediated GCN2/eIF2α pathway in mouse testes

L Gao, J Chen, J Li, AQ Cui, WW Zhang, XL Li… - Science of The Total …, 2021 - Elsevier
Previous studies demonstrated that microcystin-leucine-arginine (MC-LR) disrupted
testosterone (T) synthesis, but the underlying mechanisms are not entirely elucidated. This …

A novel Zn-MOF fluorescent probe for highly sensitive and rapid detection of gossypol in cottonseed oil and fetal bovine serum

W Li, J Zhu, X Qi, C Sun, W Li, Z Chang - Food Bioscience, 2024 - Elsevier
Gossypol is a poisonous substance in cottonseed which seriously harms the internal organs,
blood vessels, nerves, and reproductive systems of organisms. Therefore, detecting …

Risk compounds, potential mechanisms and biomarkers of traditional Chinese medicine‐induced reproductive toxicity

Q Li, X Yan, Y Zhang, J Zhou, L Yang… - Journal of Applied …, 2022 - Wiley Online Library
With the increasing application of traditional Chinese medicine (TCM), TCM‐induced
reproductive toxicity has gradually aroused people's concern. Various TCM, such as …

Gene expression pattern of Peyer's patch lymphocytes exposed to kagocel suggests pattern-recognition receptors mediate its action

AA Andreev-Andrievskiy, RA Zinovkin… - Frontiers in …, 2021 - frontiersin.org
Kagocel is a synthetic carboxymethylcellulose derivative copolymerized with gossypol.
Clinical data evidence its safety and efficiency for the treatment of flu and other viral …