The prefrontal cortex (PFC) is involved in working memory and self-regulatory and goal-
directed behaviors and displays remarkable structural and functional plasticity over the life …

The ability to discriminate among similar experiences is a crucial feature of episodic
memory. This ability has long been hypothesized to require the hippocampus, and …

The ability to encode and retrieve our daily personal experiences, called episodic memory,
is supported by the circuitry of the medial temporal lobe (MTL), including the hippocampus …

The mechanisms involved in plasticity in the nervous system are thought to support
cognition, and some of these processes are affected during normal ageing. Notably …

Ageing causes changes to the brain size, vasculature, and cognition. The brain shrinks with
increasing age and there are changes at all levels from molecules to morphology. Incidence …

Neurodegenerative disorders are characterized by extensive neuron death that leads to
functional decline, but the neurobiological correlates of functional decline in normal aging …

Pattern completion, the ability to retrieve complete memories on the basis of incomplete sets
of cues, is a crucial function of biological memory systems. The extensive recurrent …

Ice flow at a location in the equilibrium zone of the west-central Greenland Ice Sheet
accelerates above the midwinter average rate during periods of summer melting. The near …

Functional magnetic resonance imaging (fMRI) studies have observed hyperactivity in the
hippocampal region in individuals with Mild Cognitive Impairment (MCI). However, the …

When should we call an embryo or a fetus" one of us"? What is normal brain aging, and
should we simply aspire to live longer, no matter what our brain state might be? Should we …