Mast cells are innate immune cells that function as regulatory or effector cells and serve to
amplify adaptive immunity. In adaptive immunity these cells function primarily through cell …

" The beginning of wisdom is found in doubting; by doubting we come to question, and by
seeking we may come upon the truth."–Pierre Abélard CD8 is a glycoprotein expressed on …

Src homology 2 (SH2) domains are the largest family of interaction modules encoded by the
human genome to recognize tyrosine-phosphorylated sequences and thereby play pivotal …

Mouse small intestine intraepithelial lymphocytes (IEL) that express αβTCR and CD8αα
homodimers are an enigmatic T cell subset, as their specificity and in vivo function remain to …

Various subsets of invariant natural killer T (iNKT) cells with different cytokine productions
develop in the mouse thymus, but the factors driving their differentiation remain unclear …

Cellular responses elicited by cell surface receptors differ according to stimulus strength. We
investigated how the high-affinity receptor for immunoglobulin E (IgE) modulates the …

The adapter protein linker for activation of T cells (LAT) is a critical signaling hub connecting
T cell antigen receptor triggering to downstream T cell responses. In this study, we describe …

Immunotherapy strategies aim to mobilize immune defenses against tumor cells by targeting
mainly T cells. Co‐inhibitory receptors or immune checkpoints (ICPs)(such as PD-1 and …

In recent years, researchers have generated a variety of mouse models in an attempt to
dissect the contribution of individual genes to the complex phenotype associated with …

Mast cells are pivotal in innate immunity and play an important role in amplifying adaptive
immunity. Nonetheless, they have long been known to be central to the initiation of allergic …