Psoriasis is a complex long-lasting inflammatory skin disease with high prevalence and
associated comorbidity. It is characterized by epidermal hyperplasia and dermal infiltration …

Numerous scientific studies in recent years have shown significant skin and gut dysbiosis
among patients with psoriasis. A significant decrease in microbiome alpha-diversity …

Abstract The interleukin-17 (IL-17) family consists of six family members (IL-17A–IL-17F) and
all the corresponding receptors have been identified recently. This family is mainly involved …

Psoriasis is a chronic inflammatory skin disease associated with epidermal keratinocyte
hyperplasia and epidermal immune cell over-activation. Compositions of both local skin and …

IL-36R signaling plays an important role in the pathogenesis of psoriasis. We ought to
assess the specific function of IL-36R in keratinocytes for the pathology of Aldara-induced …

IL-36 is a member of the IL-1 superfamily and consists of three agonists and one receptor
antagonist (IL-36Ra). The three endogenous agonists, IL-36α,–β, and–γ, act primarily as …

Extracellular vesicles (EVs) are evaginations of the cytoplasmic membrane, containing
nucleic acids, proteins, lipids, enzymes, and toxins. EVs participate in various bacterial …

IL-36 is a most recent member of the IL-1 cytokine family, primarily expressed at barrier sites
of the body such as the skin, lungs, and intestine. It plays a vital role in inflammation and is …

The IL-36 family cytokines have emerged as important mediators of dermal inflammation in
psoriasis and have been reported to provide a proinflammatory stimulus to a variety of …

Enteropathogenic bacterial infections are a global health issue associated with high
mortality, particularly in developing countries. Efficient host protection against …