Tobacco use disorder is a chronic illness. With its high comorbidity rate, it is a major cause of
years of life lost or years lived with disability; however, it is also considered the most …

The ability to computationally predict whether a compound treats a disease would improve
the economy and success rate of drug approval. This study describes Project Rephetio to …

Advances in understanding the regulatory functions of the nervous system have revealed
neural cholinergic signaling as a key regulator of cytokine responses and inflammation …

Objective: To examine whether galantamine, a cognitive-enhancing medication that is both
acetylcholinesterase inhibitor and agonist at nicotinic acetylcholine receptors, is effective at …

Rationale The mildly euphoric and cognitive enhancing effects of nicotine play a role in the
initiation of smoking, while dysphoria and anxiety associated with smoking cessation …

Smoking causes various diseases and is a major public health threat worldwide. Therefore,
promoting smoking cessation is the most important intervention contributing to maintaining …

Rationale Nicotine use disorder can alter synaptic plasticity correlated with learning and
memory process. G protein–coupled receptor 55 (GPR55), a novel cannabinoid receptor …

Background The present study aimed to assess whether folic acid (FA) have potential to
prevent memory impairment caused by nicotine (Nico) withdrawal in adolescent male rats …

The landscape of worldwide tobacco use is changing, with a decrease in traditional smoking
and an exponential rise in electronic cigarette use. No new nicotine cessation …

Inhibition of cholinesterases remains one of a few available treatment strategies for
neurodegenerative dementias such as Alzheimer's disease and related conditions. The …