Interrupted time series (ITS) analysis is arguably the strongest quasi-experimental research
design. ITS is particularly useful when a randomized trial is infeasible or unethical. The …

ContextPrescription drugs are instrumental to managing and preventing chronic disease.
Recent changes in US prescription drug cost sharing could affect access to them …

Medical practice in the United States has changed dramatically in the last several decades,
especially with more frequent use of prescription drugs. A higher volume and better-quality …

In order to be approved for marketing in the United States, drugs must be proven to be safe
and effective using “adequate and well‐controlled investigations.” This chapter clarifies the …

ContextRising costs of medications and inequities in access have sparked calls for drug
policy reform in the United States and Canada. Control of drug expenditures by prescription …

This updated second edition of At Risk in America provides a detailed analysis of those key
population groups most vulnerable to disease and injury in the United States today …

OBJECTIVE: Novel antipsychotic medications have been reported to have beneficial effects
on cognitive functioning in patients with schizophrenia. However, these effects have been …

Discusses categories of suboptimal prescribing of medications and the modification of such
practices in older patients. Definitions of polypharmacy, inappropriate prescribing and …

Adherence to medication is one of the most intriguing and complex behaviours
demonstrated by patients. Non-adherence to a therapeutic regimen may result in negative …

We examined the prevalence of self-reported chronic conditions and out-of-pocket spending
using the 2005 Medical Expenditure Panel Survey (MEPS) and made comparisons to …