Highlights•Cryo-EM may be used to determine atomic structures of amyloid filaments
extracted from human brain tissue.•Unique protofilament folds characterise tau filaments …

Cryo–electron microscopy, or simply cryo-EM, refers mainly to three very different yet closely
related techniques: electron crystallography, single-particle cryo-EM, and electron …

The three-dimensional positions of atoms in protein molecules define their structure and
their roles in biological processes. The more precisely atomic coordinates are determined …

Public archiving in structural biology is well established with the Protein Data Bank (PDB;
wwPDB. org) catering for atomic models and the Electron Microscopy Data Bank (EMDB; …

Coronaviruses (CoVs) have caused outbreaks of deadly pneumonia in humans since the
beginning of the 21st century. The severe acute respiratory syndrome coronavirus (SARS …

A new method to estimate the trajectories of particle motion and the amount of cumulative
beam damage in electron cryo-microscopy (cryo-EM) single-particle analysis is presented …

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron
microscopy | Nature Methods Skip to main content Thank you for visiting nature.com. You are …

Single-particle electron cryomicroscopy (cryo-EM) is a powerful method for determining the
structures of biological macromolecules. With automated microscopes, cryo-EM data can …

Cryogenic electron microscopy (cryo-EM) enables structure determination of
macromolecular objects and their assemblies. Although the techniques have been …

Accurate estimation of the contrast transfer function (CTF) is critical for a near-atomic
resolution cryo electron microscopy (cryoEM) reconstruction. Here, a GPU-accelerated …