Metabolomics deals with the whole ensemble of metabolites (the metabolome). As one of
the‐omic sciences, it relates to biology, physiology, pathology and medicine; but metabolites …

In the 12 years since the publication of the first Consensus Paper of the WFSBP on
biomarkers of neurodegenerative dementias, enormous advancement has taken place in …

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of
origin and change the functions and phenotypes of other cells. These features indicate …

Objective Neurofilament light chains (NfL) are unique to neuronal cells, are shed to the
cerebrospinal fluid (CSF), and are detectable at low concentrations in peripheral blood …

Neuro-axonal injury is a key factor in the development of permanent disability in multiple
sclerosis. Neurofilament light chain in peripheral blood has recently emerged as a biofluid …

Introduction Neuronal-derived exosomal Aβ42, T-tau, and P-T181-tau have been
demonstrated to be biomarkers of Alzheimer's disease (AD). However, no study has …

Objective: To examine the effects of disease activity, disability, and disease-modifying
therapies (DMTs) on serum neurofilament light (NFL) and the correlation between NFL …

Importance There is a lack of validated biomarkers for disability progression independent of
relapse activity (PIRA) in multiple sclerosis (MS). Objective To determine how serum glial …

Background: Neuronal damage is the morphological substrate of persisting neurological
disability. Neurofilaments (Nf) are specific cytoskeletal proteins of neurons and their …

Introduction Exosomes are an emerging candidate for biomarkers of Alzheimer's disease
(AD). This study investigated whether exosomal synaptic proteins can predict AD at the …